The Effects of Smoking Withdrawal On Resting State Functional Connectivity

NCT ID: NCT01632384

Last Updated: 2017-01-31

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: NA
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-02-29
• Study Completion Date: 2012-09-30

Brief Summary

The purpose of this study is to see how the brain differs between smoking regularly and after not smoking for 24 hours. The investigators will be using an MRI machine to get the information from adult smokers and non-smokers while they lie in the scanner with their eyes closed. Smokers will be scanned when they have not smoked for 24 hrs and shortly after smoking. It is our hypothesis that brain activity will be altered after not smoking for 24 hours.

Detailed Description

The broad objective of this proposal is to identify functional neuroanatomical correlates of changes in brain functional connectivity during smoking abstinence. The investigators will measure changes in regional blood oxygenation levels using fMRI while adult smokers and non-smokers lie in the scanner with their eyes closed. Smokers will be scanned when they are abstinent from smoking for 24 hrs and shortly after smoking. Our primary hypothesis is that smoking abstinence will alter resting state brain activity (or resting state functional connectivity; RSFC) across widely distributed neural networks and that high-resolution fMRI will help in resolving the exact nature of such changes. Data will be analyzed using methods developed in our laboratory and applied to other resting state datasets. All of the procedures used in the study are well validated and introduce only minor risk to participants (e.g. blood draw; MRI).

Conditions

Smoking

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Interventions

Abstain from smoking for 24 hours

Compare smoking satiation to 24 hour smoking abstinence

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Right handed
• Drug free
• No known health problems
• Currently not taking any medication
• Uninterested in quitting smoking long term

Exclusion Criteria

• Left handed/ambidextrous
• Currently taking medication
• Interested in quitting long term

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role: collaborator

Duke University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Francis J McClernon, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Duke University

Locations

Duke Health Behavior Neuroscience Research Program

Durham, North Carolina, United States

Countries

United States

Other Identifiers

R01DA023516

Identifier Type: NIH

Identifier Source: secondary_id

View Link

Pro00031550

Identifier Type: -

Identifier Source: org_study_id