Nivestim™ in Treatment of Malignant Diseases

NCT ID: NCT01627990

Last Updated: 2015-07-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

386 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-06-30

Study Completion Date

2013-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to observe the tolerability, safety and efficacy of preventative treatment using Nivestim™ in patients receiving cytotoxic chemotherapy for cancer.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a non-interventional, descriptive, national, multi-site, longitudinal and prospective observational study with in-patients adults or minors undergoing cytotoxic chemotherapy, being treated prophylactically with Nivestim™ in order to reduce the duration of neutropenia and to reduce the incidence of chemotherapy-induced Febrile neutropenia (FN).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Solid Tumour Malignant Haematological Tumour Primary or Secondary Prophylactic Treatment

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* No age limit
* Declaration of informed consent signed by patient or legal guardian
* Patients with a solid tumour or with a malignant haematological tumour
* Patients for whom cytotoxic chemotherapy is planned, irrespective of cycle
* Patients who are due to undergo, or who should undergo, (primary or secondary) prophylactic treatment using Nivestim™, either to shorten the duration of a neutropenia or to prevent the occurrence of chemotherapy induced febrile neutropenia (FN).

Exclusion Criteria

* Patients with chronic myeloid leukaemia (CML) or with myelodysplastic Syndrome (MDS)
* Patients who are hypersensitive to the active substance or to one of the excipients of Nivestim™
* Patients not undergoing chemotherapy
* Patients being treated curatively with Granulocyte-Colony Stimulating Factor (G-CSF)
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Hospira, now a wholly owned subsidiary of Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Facharzt für Innere Medizin, Onkologie, Hämatologie

Ahaus, , Germany

Site Status

Studienzentrum Hämatologie/Onkologie/Diabetologie

Aschaffenburg, , Germany

Site Status

Facharzt für Innere Medizin Hämatologie / Onkologie

Bad Säckingen, , Germany

Site Status

MediOnko-Institut GbR

Berlin, , Germany

Site Status

Onkoplan GmbH/Onkologische Schwerpunkpraxis

Berlin, , Germany

Site Status

FA f. Frauenheilkunde und Geburtshilfe Gynäkologische Onkologie

Chemnitz, , Germany

Site Status

MVZ Delitzsch GmbH

Delitzsch, , Germany

Site Status

Gesellschaft für onkologische Studien Dortmund mbH

Dortmund, , Germany

Site Status

Gemeinschaftspraxis

Dresden, , Germany

Site Status

Gemeinschaftspraxis Haematologie/Medizin Onkologie

Düsseldorf, , Germany

Site Status

Gemeinschaftspraxis

Eisenach, , Germany

Site Status

Krankenhaus Nordwest GmbH Institut für klinische Forschung

Frankfurt am Main, , Germany

Site Status

Internist - Hämatologe - Onkologe

Garbsen, , Germany

Site Status

Onkodok GmbH

Gütersloh, , Germany

Site Status

Fachärztin für Allgemeinmedizin

Hamburg, , Germany

Site Status

Facharzt für innere Medizin

Hamburg, , Germany

Site Status

Internist - Hämatologe - Onkologe

Hanover, , Germany

Site Status

ODZ-Petersen GmbH

Heidenheim, , Germany

Site Status

DOKUSAN Gesellschaft für medizinische Studien mbH & Co. KG

Herne, , Germany

Site Status

ZAGO

Krefeld, , Germany

Site Status

FA f. Frauenheilkunde und Geburtshilfe

Leipzig, , Germany

Site Status

Pneumologisch/onkologisch/internistisches Studienzentrum

Leipzig, , Germany

Site Status

Fachübergreifende Gemeinschaftspraxis Innere Medizin, Hämatologie, Onkologie, Tumortherapie, Palliativmedizin

Lippstadt, , Germany

Site Status

Praxis für Innere Medizin, Hämatologie und Onkologie

Mainz, , Germany

Site Status

Johannes Esling Klinikum Minden

Minden, , Germany

Site Status

OnkoLog Moers GbR

Moers, , Germany

Site Status

Fachärzte für Innere Medizin - Hämatologie u. Internistische Onkologie - Bluttransfusionswesen

München, , Germany

Site Status

Forschungs- und Studiengesellschaft HOPE München GmbH

München, , Germany

Site Status

Münster, , Germany

Site Status

FÄ für Innere Medizin Hämatologie/Internistische Onkologie

Neustadt A. Rbge, , Germany

Site Status

Facharzt für Innere Medizin - Medikamentöse Tumortherapie - Palliativmedizin

Neustadt/Sachsen, , Germany

Site Status

MVZ Nordhausen gGmbH/ FA für Frauenheilkunde und Geburtshilfe

Nordhausen, , Germany

Site Status

Martha-Maria Krankenhaus gGmbH MVZ Onkologie

Nuremberg, , Germany

Site Status

Fachärztin für Innere Medizin Hämatologie u. Internistische Onkologie

Oelde, , Germany

Site Status

Onkologische Praxis Oldenburg/ Delmenhorst

Oldenburg, , Germany

Site Status

Medizinisches Versorgungszentrum Onkologische Schwerpunktpraxis

Olpe, , Germany

Site Status

Osnabrück, , Germany

Site Status

Facharzt für Innere Medizin - Hämatologie - Onkologie - Medikamentöse Tumortherapie

Remscheid, , Germany

Site Status

Frauenärzte -Naturheilverfahren-

Rodgau, , Germany

Site Status

Facharzt für Fraueneheilkunde und Geburtshilfe Gynäkologische Onkologie

Scheibenberg, , Germany

Site Status

Onkol. Managementgesellschaft Bonn/Rhein-Sieg/Ahr mbH

Siegburg, , Germany

Site Status

Medizinisches Versorgungszentrum GbR

Soest-Paradiese, , Germany

Site Status

g.SUND Gyn. Kompetenzzentrum FA f. Frauenheilkunde & Geburtshilfe SP Gynäkologie Onkologie operative Gyn./ med. Tumortherapie/ Palliativmed.

Stralsund, , Germany

Site Status

Stuttgart, , Germany

Site Status

Fachärzte für Innere Medizin -Hämatologie und Internistische Onkologie

Velbert, , Germany

Site Status

Gesellschaft zur Förderung von Wissenschaft und Qualitätssicherung in der ambulanten Onkologie (GFWQ)

Wiesbaden, , Germany

Site Status

FA f. Frauenheilkunde u. Geburtshilfe Marien-Hospital Witten gGmbH

Witten, , Germany

Site Status

FA für innere Medizin/Hämatologie und Int. Onkologie/Palliativmedizin

Zittau, , Germany

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Germany

References

Explore related publications, articles, or registry entries linked to this study.

Fruehauf S, Otremba B, Stotzer O, Rudolph C. Compatibility of Biosimilar Filgrastim with Cytotoxic Chemotherapy during the Treatment of Malignant Diseases (VENICE): A Prospective, Multicenter, Non-Interventional, Longitudinal Study. Adv Ther. 2016 Nov;33(11):1983-2000. doi: 10.1007/s12325-016-0419-1. Epub 2016 Oct 14.

Reference Type DERIVED
PMID: 27743353 (View on PubMed)

Kamioner D, Fruehauf S, Maloisel F, Cals L, Lepretre S, Berthou C. Study design: two long-term observational studies of the biosimilar filgrastim Nivestim (Hospira filgrastim) in the treatment and prevention of chemotherapy-induced neutropenia. BMC Cancer. 2013 Nov 16;13:547. doi: 10.1186/1471-2407-13-547.

Reference Type DERIVED
PMID: 24237790 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

VENICE

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Phase I Study of Intrathecal Topotecan
NCT00001333 COMPLETED PHASE1