Pilot Study of Diet and Behavior in Children With Autism

NCT ID: NCT01625299

Last Updated: 2012-06-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-10-31

Study Completion Date

2011-03-31

Brief Summary

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We hypothesize that in children with autism dietary antigens can change the intestine, making it "leaky" and then affecting the brain changing their behavior.

Detailed Description

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Subjects in 2 different diets (gluten/dairy and placebo) will be monitored for changes in intestinal permeability (urine lactulose mannitol ratio) and behavior (psychometric testing).

Conditions

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Autism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Gluten and Milk group

Subject on a gluten and dairy free diet will receive supplement of gluten and dry milk daily

Group Type EXPERIMENTAL

Gluten and dry milk

Intervention Type DIETARY_SUPPLEMENT

0.5 g/kg/day of gluten 0.5 g/kg/day of dry milk

Rice flour

Subjects will be on a gluten and dairy free diet and receive daily supplement of rice flour (placebo)

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Rice flour 1.0 g/kg/day

Interventions

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Gluten and dry milk

0.5 g/kg/day of gluten 0.5 g/kg/day of dry milk

Intervention Type DIETARY_SUPPLEMENT

Placebo

Rice flour 1.0 g/kg/day

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Gluten and dairy group Control group

Eligibility Criteria

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Inclusion Criteria

* Children between the ages of 3 and 12 years,
* DSM-IV (APA, 2000) diagnosis of Autistic Disorder (DSM-IV 299.90),
* willingness to follow and maintain a gluten-free-dairy-free-diet for 4 weeks.

Exclusion Criteria

* food allergies,
* celiac disease,
* inflammatory bowel disease,
* infectious gastrointestinal,
* seizure disorder,
* neurological problems with behavioral changes,
* unwillingness to undertake the dietary challenge with milk and gluten or to maintain a gluten-free-dairy-free-diet during the study were excluded
Minimum Eligible Age

3 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The University of Texas Health Science Center, Houston

OTHER

Sponsor Role lead

Responsible Party

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Fernando Navarro

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Fernando Navarro, M.D>

Role: PRINCIPAL_INVESTIGATOR

The University of Texas Health Science Center, Houston

Locations

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The University of Texas Health Science Center At Houston

Houston, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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HSC-MS-07-0223

Identifier Type: -

Identifier Source: org_study_id

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