Timing of Intrauterine Insemination (IUI) 24 or 48 Hours After Spontaneous Luteinizing Hormone (LH) Peak

NCT ID: NCT01622023

Last Updated: 2019-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

435 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2013-06-30

Brief Summary

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The aim of the present study is to prospectively evaluate whether performing an intra-uterine insemination 24 hours after the spontaneous LH peak may result in significantly higher ongoing pregnancy rates compared to 48 hours.

Detailed Description

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Conditions

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Pregnancy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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Study group

intrauterine insemination after 24 hours

Group Type EXPERIMENTAL

intra-uterine insemination

Intervention Type PROCEDURE

Artificial insemination is the process by which sperm is placed into the reproductive tract of a female for the purpose of impregnating the female by using means other than sexual intercourse or natural insemination.

Control group

intrauterine insemination after 48 hours

Group Type ACTIVE_COMPARATOR

intra-uterine insemination

Intervention Type PROCEDURE

Artificial insemination is the process by which sperm is placed into the reproductive tract of a female for the purpose of impregnating the female by using means other than sexual intercourse or natural insemination.

Interventions

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intra-uterine insemination

Artificial insemination is the process by which sperm is placed into the reproductive tract of a female for the purpose of impregnating the female by using means other than sexual intercourse or natural insemination.

Intervention Type PROCEDURE

Other Intervention Names

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no other interventions

Eligibility Criteria

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Inclusion Criteria

* below 39 years of age on the day of LH peak
* donor semen
* natural cycle (without CC)
* cycle with less than 3 follicles reaching 15 mm of diameter or more.
* with basal hormonal values of progesterone ( \< 1,2 ng/dl)

Exclusion Criteria

The patients excluded are women

* who underwent more than 6 intrauterine inseminations,
* with tubal infertility
Minimum Eligible Age

18 Years

Maximum Eligible Age

39 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Universitair Ziekenhuis Brussel

OTHER

Sponsor Role lead

Responsible Party

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Blockeel Christophe

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Christophe Blockeel

Brussels, , Belgium

Site Status

Countries

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Belgium

References

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Blockeel C, Knez J, Polyzos NP, De Vos M, Camus M, Tournaye H. Should an intrauterine insemination with donor semen be performed 1 or 2 days after the spontaneous LH rise? A prospective RCT. Hum Reprod. 2014 Apr;29(4):697-703. doi: 10.1093/humrep/deu022. Epub 2014 Feb 18.

Reference Type DERIVED
PMID: 24549212 (View on PubMed)

Other Identifiers

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1/2012

Identifier Type: -

Identifier Source: org_study_id

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