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Study of the Enteric Nervous System Using Colonic Biopsies in Parkinson Patients With LRRK2 Mutation

NCT ID: NCT01618383

Last Updated: 2016-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

19 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2013-10-31

Brief Summary

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The clinical and pathological similarities between LRRK2 related parkinsonism and idiopathic Parkinson's disease (PD) indicate that monogenetic LRRK2 parkinsonism may be a paradigm for the development of Lewy bodies disease, and a careful look at discrepancies between these two conditions may provide insight into the pathogenesis of PD. The early involvement of the enteric nervous system (ENS) during PD led to theories that an as yet unidentified external agent entering the ENS causes PD . If lesions of the ENS are found in patients who present with a genetic form of parkinsonism would go against this notion, and thus provide insight to the pathophysiology of the disease.

Detailed Description

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Conditions

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Parkinson's Disease

Keywords

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Parkinson's disease gut colon biopsies LRRK2

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Colonic biopsies

Colonic biopsies obtained during the course of colonoscopy or rectosigmoidoscopy

Group Type OTHER

colonoscopy or rectosigmoidoscopy

Intervention Type OTHER

Usual procedure

Interventions

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colonoscopy or rectosigmoidoscopy

Usual procedure

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients aged 30-80, both genders
* Parkinson's disease patients
* Parkinson's disease patients with G2019S mutations
* Controls: patient at risk of colic cancer for whom a coloscopy is required
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nantes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tiphaine ROUAUD, Doctor

Role: PRINCIPAL_INVESTIGATOR

Nantes University Hospital

Locations

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University Hospital

Nantes, , France

Site Status

Countries

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France

Other Identifiers

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RC11_0110

Identifier Type: -

Identifier Source: org_study_id