Effect of Acute Treatment With N2O on Inhibitory Pain Mechanisms in Healthy Subject

NCT ID: NCT01616004

Last Updated: 2014-09-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-10-31

Study Completion Date

2016-08-31

Brief Summary

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The purpose of this study is to determine whether N2O (laughing gas) has an antinociceptive effects in healthy volunteers.

Detailed Description

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10 healthy volunteers will come twice to the pain medicine unit, at 1 visit they'll get N2O and in the second visit they'll get air as placebo, they won't know what they're getting. During the visit they'll get heat stimulus using QST and will have to report their pain using eVAS (scale from 0 to 100 when 0 is no pain and 100 is the worst pain imagine).

Conditions

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Pain

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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N2O

N20 70% inhalation 5 minutes O2 100 % inhalation for 5 minutes

Group Type EXPERIMENTAL

N2O

Intervention Type DRUG

Air

Group Type SHAM_COMPARATOR

Air

Intervention Type DRUG

sham comparator

Interventions

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N2O

Intervention Type DRUG

Air

sham comparator

Intervention Type DRUG

Other Intervention Names

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laughing gas

Eligibility Criteria

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Inclusion Criteria

* 18-50 years old
* women and men
* healthy

Exclusion Criteria

* smokers
* medication use pregnant woman cardiovascular disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tel-Aviv Sourasky Medical Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Silviu Brill, MD

Role: PRINCIPAL_INVESTIGATOR

Tel-Aviv Sourasky Medical Center

Locations

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Tel Aviv Sourasky Medical Center, Pain Medicine Unit

Tel Aviv, , Israel

Site Status

Countries

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Israel

Central Contacts

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Silviu Brill, M.D

Role: CONTACT

972-3-6974477

Facility Contacts

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silviu Brill, M.D

Role: primary

972-3-6974477

Other Identifiers

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TASMC-12-SB-340-CTIL

Identifier Type: -

Identifier Source: org_study_id

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