Effect of Oral Supplementation With a Fibre Enriched Paediatric Sip Feed For Children With Acute Lymphocytic Leukemia

NCT ID: NCT01600781

Last Updated: 2015-02-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-12-31

Study Completion Date

2014-09-30

Brief Summary

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This is a randomised, controlled, open-label intervention study. It is hypothesized that supplementation with a fibre enriched sip feed will improve the nutritional status, gut microbiota and quality of life (QOL) of children with acute lymphoblastic leukemia, and may enhance their immune response. This could give them a better chance to finish their induction chemotherapy successfully with fewer side effects.

Detailed Description

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Study objectives:

Primary objective:

To evaluate the effect of oral supplementation with a fibre supplemented paediatric sip feed on the nutritional status of Egyptian children with acute lymphocytic leukemia (ALL) compared to standard dietary counseling.

Secondary objective:

To evaluate the effect of oral supplementation with a fibre supplemented paediatric sip feed on the gut microbiota and quality of life (QoL) of Egyptian children with ALL compared to standard dietary counseling.

Conditions

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Acute Lymphocytic Leukemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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NutriniDrink/Fortini group

this group will receive 2 bottles of NutriniDrink/Fortini MF unflavoured daily (200 ml each) and standard dietary counselling for a period of 6 weeks.

Group Type ACTIVE_COMPARATOR

NutriniDrink/Fortini MF unflavoured (1.5kcal/ml)

Intervention Type DIETARY_SUPPLEMENT

During the 6-week Intervention period children allocated to group 1 will consume 2 bottles of study product per day (400ml in total).

control group

this control group will only receive standard dietary counselling

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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NutriniDrink/Fortini MF unflavoured (1.5kcal/ml)

During the 6-week Intervention period children allocated to group 1 will consume 2 bottles of study product per day (400ml in total).

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Age should be above 2 years and children should be pre-pubertal.
* Hospitalized for the entire (6 week) intervention period.
* About to receive? induction chemotherapy.
* Able to tolerate oral feeding.
* Written informed consent from parents/guardian (and child, if applicable to local law).

Exclusion Criteria

* ALL patients \< 2 years and those who show signs of puberty.
* ALL patients who cannot tolerate oral feeding and/or are on parenteral nutrition.
* ALL patients with a known history of cow's milk allergy/intolerance or galactosemia.
* ALL patients requiring a fibre-free diet.
* Investigator's uncertainty about the willingness or ability of the child/carer to comply with the protocol requirements.
* Participation in any other study involving investigational or marketed products concomitantly or within two weeks prior to entry into the study.
Minimum Eligible Age

2 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Children's Cancer Hospital Egypt 57357

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alaa El-Hadad, PhD

Role: PRINCIPAL_INVESTIGATOR

Children's Cancer Hospita Egypt-57357

Locations

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Children's cancer Hospital Egypt-57357

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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CCHE-ALL001

Identifier Type: -

Identifier Source: org_study_id

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