Trial Outcomes & Findings for RESCUE Stroke Caregiver Website to Enhance Discharge Planning (NCT NCT01600131)

NCT ID: NCT01600131

Last Updated: 2023-01-17

Results Overview

Changes in depressive symptoms will be measured with the Center for Epidemiologic Studies Depression (CES-D) scale. The CES-D is a 20-item, 4-point Likert scale ranging from never (0) to most of the time (3). Possible scores range from 0-60 with higher scores indicating more symptoms. It has been used in numerous studies with caregivers and has good reliability and validity.

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 174 participants
• Primary outcome timeframe: 11 weeks after baseline
• Results posted on: 2023-01-17

Participant Flow

Participant milestones

Measure	Caregiver Education and Support problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Post-Test 1 STARTED	86	88
Post-Test 1 COMPLETED	43	73
Post-Test 1 NOT COMPLETED	43	15
Post-Test 2 STARTED	43	73
Post-Test 2 COMPLETED	43	71
Post-Test 2 NOT COMPLETED	0	2

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

RESCUE Stroke Caregiver Website to Enhance Discharge Planning

Baseline characteristics by cohort

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.	Total n=174 Participants Total of all reporting groups
Age, Continuous	59.6 years STANDARD_DEVIATION 10.1 • n=5 Participants	58.6 years STANDARD_DEVIATION 13.7 • n=7 Participants	59.1 years STANDARD_DEVIATION 12.0 • n=5 Participants
Sex: Female, Male Female	74 Participants n=5 Participants	80 Participants n=7 Participants	154 Participants n=5 Participants
Sex: Female, Male Male	12 Participants n=5 Participants	8 Participants n=7 Participants	20 Participants n=5 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	8 Participants n=5 Participants	13 Participants n=7 Participants	21 Participants n=5 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	78 Participants n=5 Participants	75 Participants n=7 Participants	153 Participants n=5 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants	1 Participants n=7 Participants	1 Participants n=5 Participants
Race (NIH/OMB) Asian	0 Participants n=5 Participants	2 Participants n=7 Participants	2 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	27 Participants n=5 Participants	18 Participants n=7 Participants	45 Participants n=5 Participants
Race (NIH/OMB) White	52 Participants n=5 Participants	59 Participants n=7 Participants	111 Participants n=5 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	7 Participants n=5 Participants	8 Participants n=7 Participants	15 Participants n=5 Participants
Education ≤ High school	27 Participants n=5 Participants	20 Participants n=7 Participants	47 Participants n=5 Participants
Education Some college/vocational school	36 Participants n=5 Participants	38 Participants n=7 Participants	74 Participants n=5 Participants
Education College graduate	23 Participants n=5 Participants	30 Participants n=7 Participants	53 Participants n=5 Participants
Relationship to stroke survivor Spouse/partner	59 Participants n=5 Participants	61 Participants n=7 Participants	120 Participants n=5 Participants
Relationship to stroke survivor Child	9 Participants n=5 Participants	16 Participants n=7 Participants	25 Participants n=5 Participants
Relationship to stroke survivor Other	18 Participants n=5 Participants	11 Participants n=7 Participants	29 Participants n=5 Participants

PRIMARY outcome

Timeframe: 11 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in depressive symptoms will be measured with the Center for Epidemiologic Studies Depression (CES-D) scale. The CES-D is a 20-item, 4-point Likert scale ranging from never (0) to most of the time (3). Possible scores range from 0-60 with higher scores indicating more symptoms. It has been used in numerous studies with caregivers and has good reliability and validity.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Depressive Symptoms at 11 Weeks	-1.8 score on a scale Standard Deviation 9.4	-1.6 score on a scale Standard Deviation 9.0

PRIMARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in depressive symptoms will be measured with the Center for Epidemiologic Studies Depression (CES-D) scale. The CES-D is a 20-item, 4-point Likert scale ranging from never (0) to most of the time (3). Possible scores range from 0-60 with higher scores indicating more symptoms. It has been used in numerous studies with caregivers and has good reliability and validity.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Depressive Symptoms at 19 Weeks	-1.3 score on a scale Standard Deviation 11.4	0.2 score on a scale Standard Deviation 11.0

PRIMARY outcome

Timeframe: 11 weeks after baseline

Changes in burden will be measured by the Short Version of the Zarit Burden Interview (S-ZBI). This 12-item instrument was reduced from the original 29-item instrument. This instrument is scored on a 5-point Likert scale ranging from 0 (never) to 4 (nearly always). Possible scores range from 0-48 with higher scores indicating higher burden. The instrument was originally developed to measure dementia caregiver burden, but, the S-ZBI has been used in stroke caregiver studies and items are appropriate for other caregiver populations.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Caregiver Burden - Zarit	-0.7 score on a scale Standard Deviation 5.7	1.3 score on a scale Standard Deviation 5.7

PRIMARY outcome

Timeframe: 19 weeks after baseline

Changes in burden will be measured by the Short Version of the Zarit Burden Interview (S-ZBI). This 12-item instrument was reduced from the original 29-item instrument. This instrument is scored on a 5-point Likert scale ranging from 0 (never) to 4 (nearly always). Possible scores range from 0-48 with higher scores indicating higher burden. The instrument was originally developed to measure dementia caregiver burden, but, the S-ZBI has been used in stroke caregiver studies and items are appropriate for other caregiver populations.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Caregiver Burden - Zarit	-0.6 score on a scale Standard Deviation 6.7	0.3 score on a scale Standard Deviation 5.6

PRIMARY outcome

Timeframe: 11 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in caregiver burden - time required will be measured by the Oberst Caregiving Burden Scale (OCBS). It contains 15 items that rate different types of caregiving tasks for stroke survivors based on perceived time and difficulty of the task. Each item is scored on a scale of 1 to 5 (total range from 15 to 75) with higher scores indicating greater time required or higher task difficulty.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Caregiver Burden - Time Required	-16.8 score on a scale Standard Deviation 14.4	-14.7 score on a scale Standard Deviation 12.9

PRIMARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in caregiver burden - time required will be measured by the Oberst Caregiving Burden Scale (OCBS). It contains 15 items that rate different types of caregiving tasks for stroke survivors based on perceived time and difficulty of the task. Each item is scored on a scale of 1 to 5 (total range from 15 to 75) with higher scores indicating greater time required or higher task difficulty.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Caregiver Burden - Time Required	-17.3 score on a scale Standard Deviation 12.7	-14.5 score on a scale Standard Deviation 13.7

PRIMARY outcome

Timeframe: 11 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in caregiver burden - task difficulty will be measured by the Oberst Caregiving Burden Scale (OCBS). The OCBS contains 15 items that rate different types of caregiving tasks for stroke survivors based on perceived time and difficulty of the task. Each item is scored on a scale of 1 to 5 (total range from 15 to 75) with higher scores indicating greater time required or higher task difficulty.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Caregiver Burden - Task Difficulty	-2.0 score on a scale Standard Deviation 8.4	-0.5 score on a scale Standard Deviation 8.2

PRIMARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in caregiver burden - task difficulty will be measured by the Oberst Caregiving Burden Scale (OCBS). The OCBS contains 15 items that rate different types of caregiving tasks for stroke survivors based on perceived time and difficulty of the task. Each item is scored on a scale of 1 to 5 (total range from 15 to 75) with higher scores indicating greater time required or higher task difficulty.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Caregiver Burden - Task Difficulty	-2.5 score on a scale Standard Deviation 7.7	-0.6 score on a scale Standard Deviation 8.3

SECONDARY outcome

Timeframe: 11 weeks after baseline

Changes in perceived stress will be measured by the Perceived Stress Scale (PSS-4). The 4-item measure asses stress experienced in the last month on a 5-point Likert scale ranging from 0 (never) to 4 (very often). Scores range from 0-16, with higher scores indicating more stress.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Perceived Stress	-0.5 score on a scale Standard Deviation 3.4	-0.2 score on a scale Standard Deviation 3.0

SECONDARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in perceived stress will be measured by the Perceived Stress Scale (PSS-4). The 4-item measure asses stress experienced in the last month on a 5-point Likert scale ranging from 0 (never) to 4 (very often). Scores range from 0-16, with higher scores indicating more stress.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Perceived Stress	-0.6 score on a scale Standard Deviation 3.0	-0.02 score on a scale Standard Deviation 3.2

SECONDARY outcome

Timeframe: 11 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in positive perceptions of caregiving will be measured by the Positive Aspects of Caregiving Scale. The scale contains 11 items scored from 1 (disagree a lot) to 5 (agree a lot). Total range from 11 to 55. Higher scores indicate more positive perceptions of caregiving.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Positive Perceptions of Caregiving	2.1 score on a scale Standard Deviation 7.2	0.1 score on a scale Standard Deviation 6.7

SECONDARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in positive perceptions of caregiving will be measured by the Positive Aspects of Caregiving Scale. The scale contains 11 items scored from 1 (disagree a lot) to 5 (agree a lot). Total range from 11 to 55. Higher scores indicate more positive perceptions of caregiving.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Positive Perceptions of Caregiving	1.1 score on a scale Standard Deviation 8.4	0.0 score on a scale Standard Deviation 7.2

SECONDARY outcome

Timeframe: 11 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Change in stroke knowledge will be measured by the Stroke Knowledge Instrument developed by the National Institutes of Health. This 7-item tool consists of true/false and multiple choice responses. Scores range from 0-7, with higher scores indicating more stroke knowledge.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Stroke Knowledge	1.3 score on a scale Standard Deviation 14.2	0.4 score on a scale Standard Deviation 15.8

SECONDARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Change in stroke knowledge will be measured by the Stroke Knowledge Instrument developed by the National Institutes of Health. This 7-item tool consists of true/false and multiple choice responses. Scores range from 0-7, with higher scores indicating more stroke knowledge.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Stroke Knowledge	0.0 score on a scale Standard Deviation 15.0	0.2 score on a scale Standard Deviation 15.0

SECONDARY outcome

Timeframe: 11 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in patient satisfaction will be measured by the General Satisfaction Subscale of the Long-Form Patient Satisfaction Questionnaire. This 6-item measure is scored from 1 (strongly agree) to 5 (strongly disagree). Total range from 6 to 30. Higher scores reflect better satisfaction with healthcare.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in General Patient Satisfaction	-0.6 score on a scale Standard Deviation 5.5	0.1 score on a scale Standard Deviation 5.0

SECONDARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in patient satisfaction will be measured by the General Satisfaction Subscale of the Long-Form Patient Satisfaction Questionnaire. This 6-item measure is scored from 1 (strongly agree) to 5 (strongly disagree). Total range from 6 to 30. Higher scores reflect better satisfaction with healthcare.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in General Patient Satisfaction	-1.6 score on a scale Standard Deviation 5.4	0.1 score on a scale Standard Deviation 5.1

SECONDARY outcome

Timeframe: 11 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Change in Veteran functional abilities will be measured by the Barthel Index, which measures patients' abilities to perform 10 self-care tasks. Response options vary for each item and are scored on 5-point increments (e.g., 0=unable, 5=needs help, 10-independent). Total scores range from 0-100 with higher scores indicating greater functional abilities.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Veteran Functional Status	8.5 score on a scale Standard Deviation 13.6	2.1 score on a scale Standard Deviation 13.3

SECONDARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Change in Veteran functional abilities will be measured by the Barthel Index, which measures patients' abilities to perform 10 self-care tasks. Response options vary for each item and are scored on 5-point increments (e.g., 0=unable, 5=needs help, 10-independent). Total scores range from 0-100 with higher scores indicating greater functional abilities.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Veteran Functional Status	5.6 score on a scale Standard Deviation 20.6	1.7 score on a scale Standard Deviation 17.2

SECONDARY outcome

Timeframe: 11 weeks after baseline

Measured by Revised Scale for Caregiver Self Efficacy - Obtaining Respite subscale (Steffen et al 2002). The subscale contains 5 items which ask caregivers to rate their level of confidence (from 0% to 100%) to ask for assistance. The subscale score is obtained by calculating the mean of the items, with a total score range of 0-100. Higher scores indicate higher self-efficacy. The subscale shows strong internal consistency and adequate test-retest reliability.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Self-efficacy - Obtaining Respite	2.0 score on a scale Standard Deviation 23.7	-1.1 score on a scale Standard Deviation 27.8

SECONDARY outcome

Timeframe: 19 weeks after baseline

Measured by Revised Scale for Caregiver Self Efficacy - Obtaining Respite subscale (Steffen et al 2002). The subscale measures caregivers' confidence to ask for assistance. The subscale contains 5 items which ask caregivers to rate their level of confidence (from 0% to 100%) that they could perform the activity. The subscale score is obtained by calculating the mean of the items, with a total score range of 0-100. Higher scores indicate higher self-efficacy. The subscale shows strong internal consistency and adequate test-retest reliability.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Self-efficacy - Obtaining Respite	4.5 score on a scale Standard Deviation 20.7	-2.7 score on a scale Standard Deviation 31.96

SECONDARY outcome

Timeframe: 11 weeks after baseline

Measured by Revised Scale for Caregiver Self Efficacy - Controlling Upsetting Thoughts subscale (Steffen et al 2002). The subscale contains 5 items which ask caregivers to rate their level of confidence (from 0% to 100%) in their ability to control negative thoughts related to caregiving. The subscale score is obtained by calculating the mean of the items, with a total score range of 0-100. Higher scores indicate higher self-efficacy. The subscale shows strong internal consistency and adequate test-retest reliability.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Self-efficacy - Controlling Upsetting Thoughts	4.7 score on a scale Standard Deviation 20.4	-3.1 score on a scale Standard Deviation 18.3

SECONDARY outcome

Timeframe: 19 weeks after baseline

Measured by Revised Scale for Caregiver Self Efficacy - Controlling Upsetting Thoughts subscale (Steffen et al 2002). The subscale contains 5 items which ask caregivers to rate their level of confidence (from 0% to 100%) in their ability to control negative thoughts related to caregiving. The subscale score is obtained by calculating the mean of the items, with a total score range of 0-100. Higher scores indicate higher self-efficacy. The subscale shows strong internal consistency and adequate test-retest reliability.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Self-efficacy - Controlling Upsetting Thoughts	4.5 score on a scale Standard Deviation 26.0	-1.2 score on a scale Standard Deviation 18.4

SECONDARY outcome

Timeframe: 11 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in health-related quality of life will be measured by the Rand 12-item Health Survey (VR-12). The VR12 items are scored on a 3-point or 5-point Likert scale. It consists of physical and emotional scales. Scores for each scale are calculated by using an algorithm and scores are standardized using a T-score metric with a mean of 50 and standard deviation of 10. Higher scores indicate better health-related quality of life. There is no composite or overall score for the VR-12.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Health-Related Quality of Life - Physical	2.2 score on a scale Standard Deviation 7.9	-1.0 score on a scale Standard Deviation 8.5

SECONDARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in health-related quality of life will be measured by the Rand 12-item Health Survey (VR-12). The VR12 items are scored on a 3-point or 5-point Likert scale. It consists of physical and emotional scales. Scores for each scale are calculated by using an algorithm and scores are standardized using a T-score metric with a mean of 50 and standard deviation of 10. Higher scores indicate better health-related quality of life. There is no composite or overall score for the VR-12.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Health-Related Quality of Life - Physical	-1.2 score on a scale Standard Deviation 7.4	-0.2 score on a scale Standard Deviation 8.5

SECONDARY outcome

Timeframe: 11 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in health-related quality of life will be measured by the Rand 12-item Health Survey (VR-12). The VR12 items are scored on a 3-point or 5-point Likert scale. It consists of physical and emotional scales. Scores for each scale are calculated by using an algorithm and scores are standardized using a T-score metric with a mean of 50 and standard deviation of 10. Higher scores indicate better health-related quality of life. There is no composite or overall score for the VR-12.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Health-Related Quality of Life - Mental Health	1.4 score on a scale Standard Deviation 7.9	0.6 score on a scale Standard Deviation 9.1

SECONDARY outcome

Timeframe: 19 weeks after baseline

Population: All data collected from the 174 participants irrespective of their completion of the study were used in analysis.

Changes in health-related quality of life will be measured by the Rand 12-item Health Survey (VR-12). The VR12 items are scored on a 3-point or 5-point Likert scale. It consists of physical and emotional scales. Scores for each scale are calculated by using an algorithm and scores are standardized using a T-score metric with a mean of 50 and standard deviation of 10. Higher scores indicate better health-related quality of life. There is no composite or overall score for the VR-12.

Outcome measures

Measure	Caregiver Education and Support n=86 Participants problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 Participants Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Change in Health-Related Quality of Life - Mental Health	2.0 score on a scale Standard Deviation 9.5	0.6 score on a scale Standard Deviation 10.9

Adverse Events

Caregiver Education and Support

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Standard Care

Serious events: 0 serious events

Other events: 1 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Measure	Caregiver Education and Support n=86 participants at risk problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.cidrr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center. Caregiver problem-solving: This is a problem-solving intervention for stroke caregivers that can be delivered shortly after the Veteran's in-patient stays followed by online, in-home sessions. The investigators will modify the traditional, problem-solving intervention by adding web-based training using interactive modules, factsheets, and tools on the investigators' previously developed and nationally available RESCUE Caregiver website (www.ciddr8.research.va.gov/rescue). The investigators will also provide on-line, skills training and application of the problem-solving approach via the RESCUE messaging center.	Standard Care n=88 participants at risk Caregivers receiving standard of care Standard Care: No intervention or treatment will be provided. The investigators will closely monitor the usual care that is provided to caregivers.
Gastrointestinal disorders Diverticulitis	0.00% 0/86 • Adverse event data were collected during participation in study (19 weeks). Caregivers were asked about adverse events during data collection sessions at 11 and 19 weeks.	1.1% 1/88 • Number of events 1 • Adverse event data were collected during participation in study (19 weeks). Caregivers were asked about adverse events during data collection sessions at 11 and 19 weeks.

Additional Information

Constance Uphold

Veterans Health Administration

Phone: 352-548-6000

Email: connie.uphold@va.gov

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place