Contribution of F18-FDG PET/CT to the Early Assessment of Pazopanib Therapy Efficacy in Advanced Soft Tissue Sarcoma

NCT ID: NCT01594203

Last Updated: 2012-05-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-05-31

Study Completion Date

2013-05-31

Brief Summary

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Soft Tissue Sarcoma (STS) is a rare tumor but can grow in different areas, for example, in 60% in limbs and about 20 % in retroperitoneum; and frequently is inoperable. Despite novel therapy in advanced cases survival is still short, approximately 12 month.

Pazopanib oral angiogenesis inhibitor was recently shown as promising drug for advanced pretreated STS.

Functional imaging especially F18-FDG PET/CT is a good modality for FDG avid tumor either for pre- / post- treatment evaluation or follow up.

Early detection of treatment response to therapy by whole body FDG PET/CT allows for change of treatment as early as possible,when the tumor is non-responsive before serious side effects appear or before depletion of body resources.

The aim of the study is to investigate the contribution of FDG PET/CT to assessment of treatment response.

Detailed Description

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Conditions

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Soft Tissue Sarcoma (STS)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Advanced Soft Tissue Sarcoma

patients with advanced Soft Tissue Sarcoma

F18-FGD PET/CT

Intervention Type OTHER

Interventions

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F18-FGD PET/CT

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with advanced Soft Tissue Sarcoma prior to pazopanib treatment

Exclusion Criteria

* Other treatment
* FDG negative tumor
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hadassah Medical Organization

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hadassah Hebrew University Medical Center

Jerusalem, , Israel

Site Status

Countries

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Israel

Central Contacts

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Marina Orevi, MD

Role: CONTACT

Daniela Katz, MD

Role: CONTACT

Facility Contacts

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Marina Orevi, MD

Role: primary

Daniela Katz, MD

Role: backup

Other Identifiers

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0103-12-HMO

Identifier Type: -

Identifier Source: org_study_id

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