Clinical Study to Assess Change in Upper Airway Geometry Between Upright and Supine Position

NCT ID: NCT01594164

Last Updated: 2012-10-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2011-04-30

Brief Summary

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In this study the changes in upper airway geometry and resistance between images, obtained in upright and supine position, will be evaluated. Therefore a Cone Beam Computed Tomography (CBCT) scan and a low dose Computed Tomography (CT) scan will be taken in a population of 20 subjects. The upright morphology will be obtained using CBCT scan while the supine upper airway geometry will be determined using a standard High Resolution Computed Tomography (HRCT) scanner.

Detailed Description

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Conditions

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Changes in Upper Airway Geometry

Keywords

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High Resolution Computed Tomography Cone Beam Computed Tomography upper airway geometry

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Interventions

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Cone Beam Computed Tomography

CBCT scan of upper airway, in upright position.

Intervention Type RADIATION

High Resolution Computed Tomography

HRCT scan of upper airway, in supine position.

Intervention Type RADIATION

Other Intervention Names

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CBCT HRCT

Eligibility Criteria

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Inclusion Criteria

* Written informed consent obtained.
* Male or female subject aged ≥ 18 years.
* BMI \< 25 kg/m2 (group 1), BMI ≥ 25 kg/m2 and \< 30 kg/m2 (group 2) and BMI ≥ 30 kg/m2 (group 3) at visit 0. BMI calculation should be repeated if the interval visit 0 - visit 1 \> 14 days.
* Female subject of childbearing potential who confirms that a contraception method was used at least two months before visit 1.

Exclusion Criteria

* Subject is under the age of legal consent.
* Subject who is pregnant or is breast-feeding.
* Subject with a history of surgery of the upper airway.
* Subject with a history of any illness that, in opinion of the investigator, might confound the results of the study or poses an additional risk to the subject by participation in the study.
* Subject is unlikely to comply with the protocol or unable to understand the nature, scope and possible consequences of the study.
* Subject who received any investigational new drug within the last 4 weeks prior to visit 1.
* Subject who has claustrophobia.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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FLUIDDA nv

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wilfried De Backer, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Antwerp

Locations

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Antwerp University Hospital

Edegem, Antwerp, Belgium

Site Status

Countries

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Belgium

Other Identifiers

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FLUI-2010-61

Identifier Type: -

Identifier Source: org_study_id