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Effect of Fruit and Vegetable Intake on Markers of Fruit and Vegetable Consumption

NCT ID: NCT01591057

Last Updated: 2012-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2012-11-30

Brief Summary

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This study will examine what contribution of 'markers' of fruit and vegetable (FV) intake in blood and urine is most closely related to FV intake. 30 healthy volunteers will be fed either 2, 5 or 8 portions of FV per day for 4 weeks (ten participants per group, randomly assigned). Volunteers will have all their food provided during the study, and will consume two meals each weekday at the University. Volunteers will complete diet and lifestyle questionnaires at the start and end of the study and will have blood and urine samples collected at 0, 2 and 4 weeks.

Detailed Description

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Single biomarkers of FV consumption, such as Vitamin C and certain carotenoids and flavonoids, have been proposed, but associations between these compounds and FV intake are relatively weak. The investigators propose that, given the complexity of FV, production of an algorithm based on a wide variety of bioactive compounds found in FV might better predict FV consumption. A controlled feeding study (30 volunteers randomised to 2, 5 or 8 portions of FV day for 4 weeks) will allow development of such an algorithm. Volunteers will be recruited by advertisement from QUB and the general public, and will have all their food provided for the 4 week period (two meals per day during the week to be consumed under supervision at the University).

Conditions

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Healthy

Keywords

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fruit vegetables biomarkers randomised controlled feeding study Fruit and vegetable intake biomarkers in healthy adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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2 Portions

Group Type EXPERIMENTAL

2 portions of fruit and vegetables per day

Intervention Type DIETARY_SUPPLEMENT

Consume 2 portions of fruit and vegetables per day

5 portions

Group Type EXPERIMENTAL

5 portions of fruit and vegetables per day

Intervention Type DIETARY_SUPPLEMENT

Consume 5 portions of fruit and vegetables per day

8 portions

Group Type EXPERIMENTAL

8 portions of fruit and vegetables per day

Intervention Type DIETARY_SUPPLEMENT

Consume 8 portions of fruit and vegetables per day

Interventions

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2 portions of fruit and vegetables per day

Consume 2 portions of fruit and vegetables per day

Intervention Type DIETARY_SUPPLEMENT

5 portions of fruit and vegetables per day

Consume 5 portions of fruit and vegetables per day

Intervention Type DIETARY_SUPPLEMENT

8 portions of fruit and vegetables per day

Consume 8 portions of fruit and vegetables per day

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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2 portions/day 5 portions/day 8 portions/day

Eligibility Criteria

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Inclusion Criteria

* 18-65 years
* Usual consumption of fruit and vegetables \<= 2 portions/day

Exclusion Criteria

* Use of any high dose vitamin, mineral or dietary supplements
* Current smoker
* BMI \> 35 kg/m2
* Inability to provide informed consent
* Excessive alcohol consumption (\>28 Units/week men or \>21 Units/week women)
* Food sensitivities or allergies that would interfere with a tolerance of a fruit and vegetable rich diet
* Medical conditions or dietary restrictions that would substantially limit inability to complete the study requirements
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Queen's University, Belfast

OTHER

Sponsor Role lead

Responsible Party

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Jayne Woodside, PhD

Reader in Clinical Biochemistry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jayne V Woodside, PhD

Role: PRINCIPAL_INVESTIGATOR

Queen's University, Belfast

Locations

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Queen's University Belfast

Belfast, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Appleton KM, McGrath AJ, McKinley MC, Draffin CR, Hamill LL, Young IS, Woodside JV. The value of facial attractiveness for encouraging fruit and vegetable consumption: analyses from a randomized controlled trial. BMC Public Health. 2018 Mar 1;18(1):298. doi: 10.1186/s12889-018-5202-6.

Reference Type DERIVED
PMID: 29490640 (View on PubMed)

McGrath AJ, Hamill LL, Cardwell CR, Draffin CR, Neville CE, Appleton KM, McEneny J, McKinley MC, Young IS, Woodside JV. Combining vitamin C and carotenoid biomarkers better predicts fruit and vegetable intake than individual biomarkers in dietary intervention studies. Eur J Nutr. 2016 Jun;55(4):1377-88. doi: 10.1007/s00394-015-0953-7. Epub 2015 Jun 17.

Reference Type DERIVED
PMID: 26081648 (View on PubMed)

Other Identifiers

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11/07

Identifier Type: -

Identifier Source: org_study_id