Effect of Litramine on Fat Excretion

NCT ID: NCT01590667

Last Updated: 2012-07-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-05-31

Study Completion Date

2012-07-31

Brief Summary

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The study aims to evaluate the effect of Litramine on fecal fat excretion in healthy subjects, to provide more comprehensive and robust clinical evidence in its mode of action for the treatment of obesity and weight management through dietary fat binding.

Detailed Description

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Conditions

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Healthy Subjects

Keywords

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Fat excretion

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Litramine

2 tablets 3 times daily (oral consumption, 30 minutes after meal)

Group Type ACTIVE_COMPARATOR

Litramine

Intervention Type DEVICE

2 tablets 3 times daily (oral consumption, 30 minutes after meal)

Placebo

2 tablets 3 times daily (oral consumption, 30 minutes after meal)

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DEVICE

2 tablets 3 times daily (oral consumption, 30 minutes after meal)

Interventions

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Litramine

2 tablets 3 times daily (oral consumption, 30 minutes after meal)

Intervention Type DEVICE

Placebo

2 tablets 3 times daily (oral consumption, 30 minutes after meal)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* BMI 20-30 kg/m2
* Accustomed to 3 main meals/day
* Commitment to avoid the use of other weight management products during study
* Females' agreement to use appropriate birth control methods during the active study period
* Self-reported regular bowel movement (1-2 times per day)
* Subject declares in writing his/her consent to participate, understands requirements of the study and is willing to comply

Exclusion Criteria

* Known sensitivity to the ingredients of the device
* Diabetes mellitus (type 1 or 2)
* History or clinical signs of endocrine disorders
* Clinically relevant excursions of safety parameter
* Current use of anti-depressants
* Presence of acute or chronic gastrointestinal disease
* Uncontrolled hypertension (more than 160/110 mm Hg)
* Stenosis in the gastrointestinal tract
* Bariatric surgery
* Abdominal surgery within the last 6 months prior to enrollment
* History of eating disorders such as bulimia, anorexia nervosa within the past 12 months
* Other serious organ or systemic diseases such as cancer
* Any medication that could influence gastrointestinal functions
* Pregnancy or nursing
* Any medication or use of products for the treatment of obesity within 6 weeks prior to enrolment
* History of abuse of drugs, alcohol or medication
* Presence of other factor(s) that, in the investigator's judgment, should preclude subject participation
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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InQpharm Group

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Regina Busch, MD

Role: PRINCIPAL_INVESTIGATOR

analyze & realize AG

Locations

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Weißenseer Weg 111

Berlin, State of Berlin, Germany

Site Status

Countries

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Germany

References

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Uebelhack R, Busch R, Alt F, Beah ZM, Chong PW. Effects of cactus fiber on the excretion of dietary fat in healthy subjects: a double blind, randomized, placebo-controlled, crossover clinical investigation. Curr Ther Res Clin Exp. 2014 Jun 21;76:39-44. doi: 10.1016/j.curtheres.2014.02.001. eCollection 2014 Dec.

Reference Type DERIVED
PMID: 25067985 (View on PubMed)

Other Identifiers

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INQ/028711

Identifier Type: -

Identifier Source: org_study_id