Trial Outcomes & Findings for Bi-Level Positive Airway Ventilation for Acute Chest Syndrome (NCT NCT01589926)

NCT ID: NCT01589926

Last Updated: 2018-12-11

Results Overview

Length of stay as measured by the time from initial diagnosis of ACS until meeting discharge criteria. It is anticipated length of stay will correlate to efficacy of treatment: shorter stay is theorized to indicate more efficient treatment.

Recruitment status

TERMINATED

Study phase

NA

Target enrollment

3 participants

Primary outcome timeframe

From diagnosis of ACS until meeting discharge criteria- Average 7 days.

Results posted on

2018-12-11

Participant Flow

Study was terminated due to low enrollment. Only three participants were enrolled and none initiated treatment.

Participant milestones

Participant milestones
Measure
Bi-level Positive Airway Pressure
BiPAP initiated for at least 16 hours per day for a minimum of 48hrs. Bi-level positive airway pressure device: BiPAP initiated for at least 16 hours per day for a minimum of 48hrs.
Sham CPAP
Physiologic CPAP initiated for at least 16 hours per day for a minimum of 48hrs. Sham CPAP: Sham CPAP initiated for at least 16 hours per day for a minimum of 48hrs.
Overall Study
STARTED
0
0
Overall Study
COMPLETED
0
0
Overall Study
NOT COMPLETED
0
0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Bi-Level Positive Airway Ventilation for Acute Chest Syndrome

Baseline characteristics by cohort

Baseline data not reported

PRIMARY outcome

Timeframe: From diagnosis of ACS until meeting discharge criteria- Average 7 days.

Population: Study was terminated due to low enrollment. Only three participants were enrolled and none initiated treatment.

Length of stay as measured by the time from initial diagnosis of ACS until meeting discharge criteria. It is anticipated length of stay will correlate to efficacy of treatment: shorter stay is theorized to indicate more efficient treatment.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Diagnosis until discharge. Average 7 days.

Population: Study was terminated due to low enrollment. Only three participants were enrolled and none initiated treatment.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Upon completion of intervention at 48hrs.

Population: Study was terminated due to low enrollment. Only three participants were enrolled and none initiated treatment.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Diagnosis until discharge. Average 7 days.

Population: Study was terminated due to low enrollment. Only three participants were enrolled and none initiated treatment.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 48hrs after initiation of treatment

Population: Study was terminated due to low enrollment. Only three participants were enrolled and none initiated treatment.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 48hrs after initiation of treatment

Population: Study was terminated due to low enrollment. Only three participants were enrolled and none initiated treatment.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 48hrs after initiation of treatment

Population: Study was terminated due to low enrollment. Only three participants were enrolled and none initiated treatment.

Peripheral capillary oxygen saturation (SpO2) is an estimate of the amount of oxygen in the blood. It is the percentage of haemoglobin containing oxygen compared to the total amount of haemoglobin in the blood (i.e. oxygenated haemoglobin vs oxygenated and non-oxygenated haemoglobin).

Outcome measures

Outcome data not reported

Adverse Events

Bi-level Positive Airway Pressure

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Sham CPAP

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Kerry Morrone, MD, Asst Prof of Pediatrics

Children's Hospital at Montefiore

Phone: 718-741-2342

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place