Topographic Changes of Retinal Layers After Resolution of Acute Retinal Detachment
NCT ID: NCT01587794
Last Updated: 2012-04-30
Study Results
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Basic Information
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COMPLETED
21 participants
OBSERVATIONAL
2010-04-30
2011-04-30
Brief Summary
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Detailed Description
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Experimental retinal detachment and reattachment models have demonstrated the recovery process of successfully reattached retina, including regrowth and reconfiguration of the photoreceptor inner and/or outer segments,reorganization of photoreceptor-RPE interface,increased synaptic terminals in the outer plexiform layer, inhibition of glial cell proliferation,and recovery of normal distribution of proteins. These microscopic changes are thought to be the reason for visual function recovery following retinal reattachment.
Recent development in spectral domain optical coherence tomography, which provides faster imaging speed and higher resolution, allows more detailed retinal layer evaluation. Previous studies using spectral domain optical coherence tomography have revealed abnormalities of retinal microstructure in reattached retina. However, these studies mainly focused on the photoreceptor layer and/or external limiting membrane, although abnormalities of various retinal layers have been revealed in previous microscopic studies. In addition, qualitative rather than quantitative analysis was performed in most of the studies, and most importantly, all previous studies were observational and comparisons between the affected and normal control regions were not performed.
The current study involves a series of recent-onset primary rhegmatogenous retinal detachment that were managed with surgical retinal reattachment. The investigators quantified the thickness of each retinal layer based on spectral domain optical coherence tomography images and compared the thicknesses of reattached regions and undetached normal regions. The primary purpose of this study was to evaluate the changes in thickness profiles of each retinal layer in reattached retina after acute RRD.
Conditions
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Keywords
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Study Design
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CASE_ONLY
CROSS_SECTIONAL
Study Groups
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retinal detachment group
Patients who were diagnosed with unilateral rhegmatogenous retinal detachment involving only the superior or inferior half of the retina and who underwent successful scleral buckling procedure or vitrectomy by a single surgeon between January 1, 2008 and April 1, 2010 were included in the study sample.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* traumatic retinal detachment
* recurred retinal detachment
* less than 6 months of follow-up after surgery
* insufficient cooperation for optical coherence tomography examination
* media opacity that would preclude acquisition of clear optical coherence tomography images
* -6.0 diopters or more of spherical equivalent
* prominent staphyloma
* history of intraocular surgery other than cataract surgery or intraocular lens implantation
* other ocular diseases that may influence the macular microstructure.
* individuals with indistinct intraretinal structure on optical coherence tomography images
* large retinal vessels at the location of thickness measurement, or epiretinal membrane
18 Years
70 Years
ALL
No
Sponsors
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Samsung Medical Center
OTHER
Responsible Party
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Se Woong, Kang
M.D.
References
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Kim JH, Park DY, Ha HS, Kang SW. Topographic changes of retinal layers after resolution of acute retinal detachment. Invest Ophthalmol Vis Sci. 2012 Oct 23;53(11):7316-21. doi: 10.1167/iovs.12-10155.
Other Identifiers
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2011-3-31
Identifier Type: -
Identifier Source: org_study_id