Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
2000 participants
OBSERVATIONAL
2012-05-01
2024-12-02
Brief Summary
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The IGOS aims to identify clinical and biological determinants and predictors of disease course and outcome in individual patients with Guillain-Barré syndrome, as early as possible after onset of disease.
Detailed Description
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This study aims to identify clinical and biological determinants and predictors of disease course and outcome in individual patients with Guillain-Barré syndrome, as early as possible after onset of disease. This information will be used to understand the diversity in clinical presentation and response to treatment of GBS. This information will also be used to develop new prognostic models to predict the clinical course and outcome accurately in individual patients with GBS.
To address these research questions it is required to conduct a prospective study with standardized collection of clinical data and biomaterials from a large group of well-defined GBS patients during a long follow-up period. Such an extensive study in a relatively rare disease as GBS can be addressed only by intensive international collaboration.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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GBS
Guillain-Barré syndrome \>1000, follow-up 1-3 years
No interventions assigned to this group
NC
Normal controls (NC)
No interventions assigned to this group
IC
Infectious controls (IC)
No interventions assigned to this group
OND
Other neurological diseases (OND)
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Inclusion of all males and females of all ages, independent of disease severity and treatment
* Inclusion within two weeks of onset of weakness
* Inclusion of patients transferred from another hospital if the stay in the first hospital was less than one week
* Opportunity to conduct a follow-up of at least one year
* Informed consent of patient or, in case of children, of parents or legal guardians
ALL
No
Sponsors
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Erasmus Medical Center
OTHER
Responsible Party
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Dr. B.C. Jacobs
Principal Investigator
Principal Investigators
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Bart Jacobs, Dr.
Role: PRINCIPAL_INVESTIGATOR
Erasmus Medical Center
Locations
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Barrows Neurological Institute
Phoenix, Arizona, United States
UC Irvine Health
Orange, California, United States
Yale University School of medicine
New Haven, Connecticut, United States
University of Florida
Jacksonville, Florida, United States
Northwestern University
Chicago, Illinois, United States
Southern Illinois University School of Medicine
Springfield, Illinois, United States
University of Iowa
Iowa City, Iowa, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
University of Maryland School of Medicine
Baltimore, Maryland, United States
Johns Hopkins
Baltimore, Maryland, United States
Lahey clinic Boston
Boston, Massachusetts, United States
Tufts University School of Medicine
Boston, Massachusetts, United States
Spectrum Health System
Grand Rapids, Michigan, United States
University of Minnesota
Minneapolis, Minnesota, United States
Robert Wood Johnson Medical School
New Brunswick, New Jersey, United States
University of New Mexico
Albuquerque, New Mexico, United States
University at Buffalo
Buffalo, New York, United States
Mt. Sinai School of Med
New York, New York, United States
Columbia University
New York, New York, United States
Montefiore MC
New York, New York, United States
Wexner Medical Center at The Ohio State University
Columbus, Ohio, United States
University of Tennessee
Memphis, Tennessee, United States
UT Southwestern
Dallas, Texas, United States
The university of Texas Health Science Center
Houston, Texas, United States
University of Utah School of Medicine
Salt Lake City, Utah, United States
University of Vermont College of Medicine
Burlington, Vermont, United States
Hospital Austral
Buenos Aires, , Argentina
Hospital Britanico
Buenos Aires, , Argentina
Hospital Cesar Milstein
Buenos Aires, , Argentina
Hospital de Clinicas
Buenos Aires, , Argentina
Hospital Fleni
Buenos Aires, , Argentina
Hospital Garrahan
Buenos Aires, , Argentina
Hospital Militar
Buenos Aires, , Argentina
Royal Melbourne Hospital
Parkville, Victoria, Australia
Concord Repatriation General Hospital Sydney
Sydney, , Australia
Dhaka Medical College & Hospital
Dhaka, , Bangladesh
ICDDR,B
Dhaka, , Bangladesh
Clinique Universitaire St. Luc
Brussels, , Belgium
University Hospital Leuven
Leuven, , Belgium
University of Calgary
Calgary, , Canada
Queens University
Kingston, , Canada
University hospital LHSC
London, , Canada
University Health Network
Toronto, , Canada
Renmin Hospital of Wuhan University
Wuhan, Hubei, China
Xiang Hospital Central South University
Changsha, Hunan, China
The affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China
Affiliated Hospital of Jining Medical University
Jining, Shandong, China
Aalborg Hospital
Aalborg, , Denmark
Aarhus University Hospital
Aarhus, , Denmark
National Hospital Copenhagen
Copenhagen, , Denmark
Glostrup Hospital Copenhagen
Glostrup Municipality, , Denmark
Odense University Hospital
Odense, , Denmark
Hôpital St. Louis de Paris
Paris, Paris, France
Hospital de la Timone
Marseille, , France
Nantes University Hospital
Nantes, , France
University Strassbourg
Strasbourg, , France
Universitätsklinikum der RWTH
Aachen, , Germany
University of Cologne
Cologne, , Germany
Universitatsklinikum Dresden
Dresden, , Germany
Heinrich Heine University
Düsseldorf, , Germany
University Hospital of Saarland
Homburg, , Germany
Universitatsklinikum Würzburg
Würzburg, , Germany
University of Thessaly
Larissa, Thessaly, Greece
University of Genova
Genova, , Italy
Ospedale Sant'Andrea La Spezia
La Spezia, , Italy
Ospedale Luigi Sacco
Milan, , Italy
Ospedale San Raffaele
Milan, , Italy
University of Milan
Milan, , Italy
University of Modena
Modena, , Italy
University of Milano-Bicocca
Monza, , Italy
Universita FedericoII di Napoli
Napoli, , Italy
University of Padova
Padua, , Italy
Policlinico Tor Vergata
Roma, , Italy
Sant' Andrea Hospital
Rome, , Italy
Chiba University School of Medicine
Chiba, , Japan
Kinki University School of Medicine
Osaka, , Japan
Hokkaido Medical Center
Sapporo, , Japan
Dokkyo Medical Univeristy
Tochigi, , Japan
National Defense Medical College
Tokorozawa, , Japan
Toho University Medical Center
Tokyo, , Japan
University of Malaya
Kuala Lumpur, , Malaysia
Erasmus Medical Center
Rotterdam, South Holland, Netherlands
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, , Netherlands
AMC Amsterdam
Amsterdam, , Netherlands
Gelre ziekenhuis
Apeldoorn, , Netherlands
Rode Kruis Ziekenhuis
Beverwijk, , Netherlands
Reinier de Graaf Groep
Delft, , Netherlands
Van Weel-Bethesda Hospital
Dirksland, , Netherlands
Albert Schweitzer Hospital
Dordrecht, , Netherlands
Elkerliek hospital
Helmond, , Netherlands
Westfriesgasthuis Hoorn
Hoorn, , Netherlands
LUMC
Leiden, , Netherlands
University Hospital Maastricht
Maastricht, , Netherlands
CWZ Nijmegen
Nijmegen, , Netherlands
Maasstad Hospital
Rotterdam, , Netherlands
Sint Franciscus Gasthuis
Rotterdam, , Netherlands
SSVZ
Schiedam, , Netherlands
HAGA ziekenhuis
The Hague, , Netherlands
MCH Westeinde
The Hague, , Netherlands
St. Elisabeth hospital
Tilburg, , Netherlands
University of Puerto Rico
San Juan, , Puerto Rico
University of Cape Town
Cape Town, , South Africa
Hospital de Bellvitge
Barcelona, , Spain
Hospital Santa Creu I Sant Pau
Barcelona, , Spain
Hospital Universitario Reina Sofia
Córdoba, , Spain
Clinica Hospital 2 de Octubre
Madrid, , Spain
Hospital Universitario Infanta Sofia
Madrid, , Spain
Hospital Universitario Central de Asturias
Oviedo, , Spain
Complejo Hospitalario de Navarra
Pamplona, , Spain
Hospital Marques de Valdecilla
Santander, , Spain
Hospital de Santiago
Santiago de Compostela, , Spain
Hospital Virgen de Sevilla
Seville, , Spain
Universityhospital Bern, Inselspital
Bern, , Switzerland
HFR - Cantonal Hospital
Fribourg, , Switzerland
Hôpitaux Universitaires de Genève
Geneva, , Switzerland
Lausanne University Hospital
Lausanne, , Switzerland
Ospeale Civico Lugano
Lugano, , Switzerland
Kantonspital St. Gallen
Sankt Gallen, , Switzerland
Hopital du Valais
Sion, , Switzerland
National Taiwan University Hospital
Taipei, , Taiwan
Queen Elizabeth Hospital
Birmingham, , United Kingdom
Bradford Royal Infirmary
Bradford, , United Kingdom
Addenbrooke's Hospital
Cambridge, , United Kingdom
Western General Hospital
Edinburgh, , United Kingdom
University of Glasgow
Glasgow, , United Kingdom
Hinching Brooke Hospital
Huntingdon, , United Kingdom
NHS Forth Valley Hospital
Larbert, , United Kingdom
Leeds General Infirmary
Leeds, , United Kingdom
The Walton Centre
Liverpool, , United Kingdom
Charing Cross Hospital
London, , United Kingdom
King's College Hospital
London, , United Kingdom
National Hospital of Neurology and Neurosurgery
London, , United Kingdom
St. George's Hospital
London, , United Kingdom
James Cook University Hospital
Middlesbrough, , United Kingdom
Royal Victoria Infirmary
Newcastle, , United Kingdom
University of Oxford
Oxford, , United Kingdom
Royal Hallamshire Hospital
Sheffield, , United Kingdom
Pinderfields Hospital
Wakefield, , United Kingdom
Countries
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References
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Doets AY, Lingsma HF, Walgaard C, Islam B, Papri N, Davidson A, Yamagishi Y, Kusunoki S, Dimachkie MM, Waheed W, Kolb N, Islam Z, Mohammad QD, Harbo T, Sindrup SH, Chavada G, Willison HJ, Casasnovas C, Bateman K, Miller JAL, van den Berg B, Verboon C, Roodbol J, Leonhard SE, Benedetti L, Kuwabara S, Van den Bergh P, Monges S, Marfia GA, Shahrizaila N, Galassi G, Pereon Y, Burmann J, Kuitwaard K, Kleyweg RP, Marchesoni C, Sedano Tous MJ, Querol L, Illa I, Wang Y, Nobile-Orazio E, Rinaldi S, Schenone A, Pardo J, Vermeij FH, Lehmann HC, Granit V, Cavaletti G, Gutierrez-Gutierrez G, Barroso FA, Visser LH, Katzberg HD, Dardiotis E, Attarian S, van der Kooi AJ, Eftimov F, Wirtz PW, Samijn JPA, Gilhuis HJ, Hadden RDM, Holt JKL, Sheikh KA, Karafiath S, Vytopil M, Antonini G, Feasby TE, Faber CG, Gijsbers CJ, Busby M, Roberts RC, Silvestri NJ, Fazio R, van Dijk GW, Garssen MPJ, Straathof CSM, Gorson KC, Jacobs BC; IGOS Consortium. Predicting Outcome in Guillain-Barre Syndrome: International Validation of the Modified Erasmus GBS Outcome Score. Neurology. 2022 Feb 1;98(5):e518-e532. doi: 10.1212/WNL.0000000000013139. Epub 2021 Dec 22.
Jacobs BC, van den Berg B, Verboon C, Chavada G, Cornblath DR, Gorson KC, Harbo T, Hartung HP, Hughes RAC, Kusunoki S, van Doorn PA, Willison HJ; IGOS Consortium. International Guillain-Barre Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barre syndrome. J Peripher Nerv Syst. 2017 Jun;22(2):68-76. doi: 10.1111/jns.12209.
Related Links
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link to website
Other Identifiers
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3290
Identifier Type: OTHER
Identifier Source: secondary_id
MEC-2011-477
Identifier Type: -
Identifier Source: org_study_id