Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

NCT ID: NCT01574703

Last Updated: 2016-12-29

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

4595 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-05-31

Study Completion Date

2015-07-31

Brief Summary

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Non-treatment extension to study A3051123, aimed at collecting data on cardiovascular safety for all participants in the A3051123 trial for an additional 28 weeks, allowing for a total of 52 weeks of cardiovascular safety data collection.

Detailed Description

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This study is an extension protocol for study A3051123. No treatment is provided during this study. This study is to monitor for cardiovascular events 28 weeks after completion of A3051123. This study is an extension protocol for study A3051123. No treatment is provided during this study. This study is to monitor for cardiovascular events 28 weeks after completion of A3051123.

Conditions

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Smoking Cessation

Keywords

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smoking cessation psychiatric disease cardiovascular events

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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placebo

Group Type EXPERIMENTAL

placebo

Intervention Type DRUG

All dosing to have taken place per study A3051123

varenicline

Group Type EXPERIMENTAL

varenicline tartrate

Intervention Type DRUG

All dosing to have taken place per study A3051123

bupropion

Group Type EXPERIMENTAL

bupropion hydrochloride

Intervention Type DRUG

All dosing to have taken place per study A3051123

Nicotine Replacement Therapy Patch

Group Type EXPERIMENTAL

Nicotine Replacement Therapy Patch

Intervention Type DRUG

All dosing to have taken place per study A3051123

Interventions

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placebo

All dosing to have taken place per study A3051123

Intervention Type DRUG

varenicline tartrate

All dosing to have taken place per study A3051123

Intervention Type DRUG

bupropion hydrochloride

All dosing to have taken place per study A3051123

Intervention Type DRUG

Nicotine Replacement Therapy Patch

All dosing to have taken place per study A3051123

Intervention Type DRUG

Other Intervention Names

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Chantix; Champix Zyban NRT

Eligibility Criteria

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Inclusion Criteria

* Subjects will be eligible if they were randomized to study A3051123.

Exclusion Criteria

* Participation in study A3051123 ceased (ie, withdrew consent, lost to follow-up, etc) prior to final visit of study A3051123.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Coastal Clinical Research, Inc.

Mobile, Alabama, United States

Site Status

Pharmacology Research Institute

Encino, California, United States

Site Status

Synergy Clinical Research Center of Escondido

Escondido, California, United States

Site Status

Sun Valley Research Center

Imperial, California, United States

Site Status

Omega Clinical Trials

La Habra, California, United States

Site Status

Pacific Treatment and Research Center

La Jolla, California, United States

Site Status

Pharmacology Research Institute

Los Alamitos, California, United States

Site Status

Pharmacology Research Institute (PRI)

Newport Beach, California, United States

Site Status

North County Clinical Research

Oceanside, California, United States

Site Status

NRC Research Institute

Orange, California, United States

Site Status

California Neuroscience Research Medical Group, Inc.

Sherman Oaks, California, United States

Site Status

University of Colorado Anschutz Medical Campus Behavioral Health and Wellness Program

Aurora, Colorado, United States

Site Status

Western Affiliated Research Institute

Denver, Colorado, United States

Site Status

Comprehensive Psychiatric Care

Norwich, Connecticut, United States

Site Status

Neuropsychiatric Research Center of Southwest Florida

Fort Myers, Florida, United States

Site Status

Broward Research Group

Hollywood, Florida, United States

Site Status

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Site Status

Clinical Neuroscience Solutions

Jacksonville, Florida, United States

Site Status

Renstar Medical Research

Ocala, Florida, United States

Site Status

Ocala Psychiatric Associates

Ocala, Florida, United States

Site Status

Clinical Neuroscience Solutions Inc.

Orlando, Florida, United States

Site Status

Meridien Research

Tampa, Florida, United States

Site Status

Northwest Behavioral Research Center

Marietta, Georgia, United States

Site Status

Clinical Research Atlanta

Stockbridge, Georgia, United States

Site Status

Advanced Clinical Research

Meridian, Idaho, United States

Site Status

Baber Research Group Incorporated

Naperville, Illinois, United States

Site Status

Davis Clinic, Incorporated

Indianapolis, Indiana, United States

Site Status

American Health Network of IN, LLC

Indianapolis, Indiana, United States

Site Status

Goldpoint Clinical Research, LLC

Indianapolis, Indiana, United States

Site Status

Vince & Associates Clinical Research, Inc.

Overland Park, Kansas, United States

Site Status

Vince & Associates Clinical Research, Inc.

Overland Park, Kansas, United States

Site Status

Vince and Associates Clinical Research, Inc.

Overland Park, Kansas, United States

Site Status

Heartland Research Associates, LLC

Wichita, Kansas, United States

Site Status

Central Kentucky Research Associates, Incorporated

Lexington, Kentucky, United States

Site Status

Kentucky Research Group

Louisville, Kentucky, United States

Site Status

The Center for Sexual Health

Metairie, Louisiana, United States

Site Status

Maine Research Associates

Auburn, Maine, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Milford Emergency Associates, Incorporated

Milford, Massachusetts, United States

Site Status

University of Minnesota - TC

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

Precise Research Centers

Flowood, Mississippi, United States

Site Status

The Center for Pharmaceutical Research, PC

Kansas City, Missouri, United States

Site Status

Mercy Health Research

St Louis, Missouri, United States

Site Status

CRI Worldwide, LLC

Marlton, New Jersey, United States

Site Status

Global Medicinal Institutes, LLC; Princeton Medical Institute

Princeton, New Jersey, United States

Site Status

SPRI Clinical Trails LLC

Brooklyn, New York, United States

Site Status

Regional Clinical Research, Incorporated

Endwell, New York, United States

Site Status

PMG Research of Raleigh, LLC

Cary, North Carolina, United States

Site Status

Wake Internal Medicine Consultants, Inc

Raleigh, North Carolina, United States

Site Status

Wake Research Associates, LLC

Raleigh, North Carolina, United States

Site Status

Midwest Clinical Research Center

Dayton, Ohio, United States

Site Status

Oregon Health and Science University

Portland, Oregon, United States

Site Status

Southeastern PA Medical Institute

Broomall, Pennsylvania, United States

Site Status

Belmont Center for Comprehensive Treatment

Philadelphia, Pennsylvania, United States

Site Status

Lincoln Research, LLC

Lincoln, Rhode Island, United States

Site Status

Coastal Carolina Research Center

Mt. Pleasant, South Carolina, United States

Site Status

Volunteer Research Group

Knoxville, Tennessee, United States

Site Status

Clinical Neuroscience Solutions,Inc

Memphis, Tennessee, United States

Site Status

Clinical Research Associates, Inc.

Nashville, Tennessee, United States

Site Status

James G. Kyser, MD

Nashville, Tennessee, United States

Site Status

Future Search Clinical Trials

Austin, Texas, United States

Site Status

InSite Clinical Research

DeSoto, Texas, United States

Site Status

The University of Texas M.D. Anderson Cancer Center

Houston, Texas, United States

Site Status

Clinical Research Associates of Tidewater, Inc

Norfolk, Virginia, United States

Site Status

Centro de Investigacion Clinica WM

Capital Federal, Buenos Aires, Argentina

Site Status

Centro Medico Dra. De Salvo

Buenos Aires, Buenos Aires F.D., Argentina

Site Status

Monash Alfred Psychiatry Research Centre

Melbourne, Victoria, Australia

Site Status

Hospital Sao Lucas da PUCRS - Uniao Brasileira de Educacao e Assistencia

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Hospital e Maternidade Celso Pierro - Pontifícia Universidade Católica de Campinas - Campus II

Campinas, São Paulo, Brazil

Site Status

Jaqueline Scholz Issa e Mario Issa de cardiologia Ltda

São Paulo, São Paulo, Brazil

Site Status

Mental Health Center "Prof. Dr. Ivan Temkov-Bourgas" Ltd.

Burgas, Bourgas, Bulgaria

Site Status

MHAT "Dr. Hristo Stambolski" Ltd.

Kazanlak, , Bulgaria

Site Status

NPH "Sv. Ivan Rilski"

Novi Iskar, , Bulgaria

Site Status

UMHAT "Dr. Georgi Stranski" Ltd.

Pleven, , Bulgaria

Site Status

UMHAT "Sveti Georgi" Ltd.

Plovdiv, , Bulgaria

Site Status

SHATPPD - Ruse Ltd.

Rousse, , Bulgaria

Site Status

Mental Health Center - Ruse Ltd.

Rousse, , Bulgaria

Site Status

MHATNP "Sveti Naum" Ltd.

Sofia, , Bulgaria

Site Status

MHATNP Sveti Naum SJsc.

Sofia, , Bulgaria

Site Status

SHATPD - Troyan Ltd.

Troyan Municipality, , Bulgaria

Site Status

Hamilton Medical Research Group

Hamilton, Ontario, Canada

Site Status

Medical Research Associates

Mississauga, Ontario, Canada

Site Status

University of Ottawa Heart Institute

Ottawa, Ontario, Canada

Site Status

Canadian Phase Onward Inc.

Toronto, Ontario, Canada

Site Status

Centre for Addiction and Mental Health (CAMH)

Toronto, Ontario, Canada

Site Status

Diex Research Sherbrooke Inc.

Sherbrooke, Quebec, Canada

Site Status

Hospital Regional de Talca, Unidad de Enfermedades Respiratorias

Talca, Maule Region, Chile

Site Status

Centro Respiratorio Integral (CENRESIN Ltda.)

Quillota, Valparaiso, V Region, Chile

Site Status

CCBR A/S

Ballerup Municipality, , Denmark

Site Status

CCBR A/S

Vejle, , Denmark

Site Status

Mehiläinen Leppävaara

Espoo, Finland, Finland

Site Status

Savon Psykiatripalvelu Oy

Kuopio, Finland, Finland

Site Status

Oulu Mentalcare Oy

Oulu, Finland, Finland

Site Status

Mehiläinen Nummela

Nummela, , Finland

Site Status

Porin Lääkäritalo Oy

Pori, , Finland

Site Status

PEL, Psykiatrian ErikoisLääkärit

Turku, , Finland

Site Status

Universitaetsklinikum Freiburg

Freiburg im Breisgau, Baden-Wurttemberg, Germany

Site Status

Ludwig Maximilians-Universitaet Muenchen

Munich, Bavaria, Germany

Site Status

Klinische Forschung Hamburg GmbH

Hamburg, City state of Hamburg, Germany

Site Status

Klinische Forschung Berlin-Mitte GmbH

Berlin, , Germany

Site Status

emovis GmbH

Berlin, , Germany

Site Status

ZSL - Zentrum fuer Medizinische Studien Leipzig GmbH

Leipzig, , Germany

Site Status

Universitaetsklinik Tuebingen, Klinik fuer Psychiatrie und Psychotherapie

Tübingen, , Germany

Site Status

Consultorios de Medicina Especializada del Sector Privado

México, Mexico Df, Mexico

Site Status

Centro de Estudios Clinicos y Especialidades Medicas S.C.

Monterrey, Nuevo León, Mexico

Site Status

Lakeland Clinical Trials

Rotorua, , New Zealand

Site Status

FSBI "Federal Medical Research Center of Psychiatry and Addiction Medicine"

Moscow, , Russia

Site Status

Moscow State Public Healthcare Institution Mental Clinical Hospital #1 n.a. N.A. Alexeeva

Moscow, , Russia

Site Status

Clinical Mental Hospital #12 of Moscow Healthcare Department

Moscow, , Russia

Site Status

Clinical Psychiatric Hospital #1 of Nizhni Novgorod

Nizhny Novgorod, , Russia

Site Status

St. Petersburg State Healthcare Institution, St. Nikolay Chudotvorets Mental Hospital

Saint Petersburg, , Russia

Site Status

FSBI "Saint-Petersburg Scientific Research Psychoneurological Institute n.a. V.M. Bekhterev"

Saint Petersburg, , Russia

Site Status

State Healthcare Institution of St.Petersburg "Psychoneurological Dispensary #2

Saint Petersburg, , Russia

Site Status

Psychiatricka ambulancia, Mentum, s.r.o.

Bratislava, , Slovakia

Site Status

Nestatna psychiatricka ambulancia, MUDr. Livia Vavrusova, PhD

Bratislava, , Slovakia

Site Status

Psychiatricka ambulancia MUDr. Nada Kuriackova, s.r.o.

Levice, , Slovakia

Site Status

Psychiatricka ambulancia, PsychoLine s.r.o.

Rimavská Sobota, , Slovakia

Site Status

Nemocnica s poliklinikou sv. Barbory Roznava a.s.

Rožňava, , Slovakia

Site Status

Flexivest Fourteen Research Center

Bellville, Cape Town, South Africa

Site Status

Worthwhile Clinical Trials

Benoni, Johannesburg, Gauteng, South Africa

Site Status

Soweto Clinical Trials Centre

Johannesburg, Gauteng, South Africa

Site Status

Midrand Medical Centre

Midrand, Gauteng, South Africa

Site Status

I Engelbrecht Research Pty. Ltd

Pretoria, Gauteng, South Africa

Site Status

Vista Clinic

Pretoria, Gauteng, South Africa

Site Status

Private Practice

Durban, Kwa-zulu Natal, South Africa, South Africa

Site Status

Randles Road Medical Centre

Durban, KwaZulu-Natal, South Africa

Site Status

Dr John O'Brien Incorporated

Cape Town, Western Cape, South Africa

Site Status

Hospital de La Santa Creu I Sant Pau

Barcelona, Barcelona, Spain

Site Status

Hospital General Universitari Vall D'Hebron

Barcelona, Barcelona, Spain

Site Status

Hospital Clinic I Provincial

Barcelona, Barcelona, Spain

Site Status

Hospital San Pedro de Alcantara

Cáceres, Caceres, Spain

Site Status

Unidad Especializada En Tabaquismo de La Comunidad de Madrid

Madrid, Madrid, Spain

Site Status

Centro de Salud Torrero-La Paz.

Zaragoza, Zaragoza, Spain

Site Status

Countries

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United States Argentina Australia Brazil Bulgaria Canada Chile Denmark Finland Germany Mexico New Zealand Russia Slovakia South Africa Spain

References

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Benowitz NL, Pipe A, West R, Hays JT, Tonstad S, McRae T, Lawrence D, St Aubin L, Anthenelli RM. Cardiovascular Safety of Varenicline, Bupropion, and Nicotine Patch in Smokers: A Randomized Clinical Trial. JAMA Intern Med. 2018 May 1;178(5):622-631. doi: 10.1001/jamainternmed.2018.0397.

Reference Type DERIVED
PMID: 29630702 (View on PubMed)

Related Links

Other Identifiers

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2011-005513-37

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

CATS

Identifier Type: OTHER

Identifier Source: secondary_id

A3051148

Identifier Type: -

Identifier Source: org_study_id