Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2012-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the efficacy and safety of two different loading doses of Clopidogrel and a reloading of Atorvastatin in the prevention of periprocedural ischemic brain damage in patients undergoing carotid angioplasty.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Ticagrelor Versus Clopidogrel in Carotid Artery Stenting

NCT02677545

Carotid Artery Stenosis

COMPLETED PHASE2

Residual Platelet Reactivity in Patients on Antiplatelet Therapy After Carotid Angioplasty With Stenting

NCT01449617

Carotid Artery Disease

UNKNOWN

Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery

NCT01146301

Carotid Stenosis

COMPLETED PHASE4

Optimized Duration of Clopidogrel Therapy Following Treatment With the Endeavor - Optimize Trial

NCT01113372

Coronary Artery Disease

COMPLETED PHASE4

Anticoagulation in Stent Intervention

NCT01141153

Atrial Fibrillation Stroke

UNKNOWN PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Carotid Stenosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Antiplatelet before carotid artery stenting

Clopidogrel 600 mg after carotid artery stenting

Group Type ACTIVE_COMPARATOR

Clopidogrel

Intervention Type DRUG

Loading dose of Clopidogrel 600 mg versus 300 mg before carotid artery stenting

Statin therapy before carotid artery stenting

Reloading dose of Atorvastatin (80 mg at 12 hours and 40 mg at 6-8 hours before carotid artery stenting) versus no reload.

Group Type ACTIVE_COMPARATOR

Atorvastatin

Intervention Type DRUG

Reloading dose of Atorvastatin (80 mg at 12 hours and 40 mg at 6-8 hours before carotid artery stenting) versus no reload.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Clopidogrel

Loading dose of Clopidogrel 600 mg versus 300 mg before carotid artery stenting

Intervention Type DRUG

Atorvastatin

Reloading dose of Atorvastatin (80 mg at 12 hours and 40 mg at 6-8 hours before carotid artery stenting) versus no reload.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* symptomatic and asymptomatic patients with finding of significant carotid stenosis

Exclusion Criteria

* patients with acute injuries to the baseline MRI of the brain,
* patients with active bleeding,
* contraindications to statin therapy and MRI contraindications (pacemaker/claustrophobic).

Minimum Eligible Age

50 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No