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Clinical and Genetic Factors Associated With Psychotic Symptoms Among Cocaine Abusers

NCT ID: NCT01569347

Last Updated: 2016-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

417 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-04-30

Study Completion Date

2016-11-30

Brief Summary

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The aim of this study is to determine the clinical, genetic and environmental factors associated with the phenotype "severe psychotic symptoms" caused by cocaine.

Detailed Description

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The second purpose is to include gene x environment interaction and to analyse the factors associated with the presence or the absence of severe psychotic symptoms induced by cocaine.

Conditions

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Cocaine-induced Psychotic Disorder During Intoxication

Keywords

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Cocaine Cocaine-induced psychosis Genetic Clinical Biological

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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1: Cocaine users

Adults, cocaine users

Interviews

Intervention Type OTHER

Interviews

Blood sample

Intervention Type OTHER

Blood sample

Hair sample

Intervention Type OTHER

Hair sample

Interventions

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Interviews

Interviews

Intervention Type OTHER

Blood sample

Blood sample

Intervention Type OTHER

Hair sample

Hair sample

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults, cocaine users, who have signed an informed consent

Exclusion Criteria

* Poor venous condition (for blood samples), specially protected people, non French speaking, people who refuse to sign the consent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Florence VORSPAN, MD, MSC

Role: PRINCIPAL_INVESTIGATOR

Assistance Publique - Hôpitaux de Paris

Locations

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Espace Murger, Hôpital Fernand Widal

Paris, , France

Site Status

Countries

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France

References

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Vorspan F, Fortias M, Zerdazi el-H, Karsinti E, Bloch V, Lepine JP, Bellivier F, Brousse G, van den Brink W, Derks EM. Self-reported cue-induced physical symptoms of craving as an indicator of cocaine dependence. Am J Addict. 2015 Dec;24(8):740-3. doi: 10.1111/ajad.12303. Epub 2015 Nov 6.

Reference Type RESULT
PMID: 26541796 (View on PubMed)

Karsinti E, Jarroir M, Zerdazi el-H, Bloch V, Dupuy G, Belforte B, Coeuru P, Plat A, Deschenau A, Cottencin O, Gay A, Lack P, Pelissier-Alicot AL, Bellivier F, Lepine JP, Brousse G, Vorspan F. Childhood trauma are not associated with the intensity of transient cocaine induced psychotic symptoms. Psychiatry Res. 2015 Aug 30;228(3):941-4. doi: 10.1016/j.psychres.2015.05.065. Epub 2015 Jun 27.

Reference Type RESULT
PMID: 26154812 (View on PubMed)

Vorspan F, Brousse G, Bloch V, Bellais L, Romo L, Guillem E, Coeuru P, Lepine JP. Cocaine-induced psychotic symptoms in French cocaine addicts. Psychiatry Res. 2012 Dec 30;200(2-3):1074-6. doi: 10.1016/j.psychres.2012.04.008. Epub 2012 May 1.

Reference Type RESULT
PMID: 22551940 (View on PubMed)

Brousse G, Vorspan F, Ksouda K, Bloch V, Peoc'h K, Laplanche JL, Mouly S, Schmidt J, Llorca PM, Lepine JP. Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. Med Hypotheses. 2010 Dec;75(6):600-4. doi: 10.1016/j.mehy.2010.07.043.

Reference Type RESULT
PMID: 20801583 (View on PubMed)

Icick R, Vorspan F, Karsinti E, Ksouda K, Lepine JP, Brousse G, Mouly S, Bellivier F, Bloch V. Gender-specific study of recurrent suicide attempts in outpatients with multiple substance use disorders. J Affect Disord. 2018 Dec 1;241:546-553. doi: 10.1016/j.jad.2018.08.076. Epub 2018 Aug 13.

Reference Type DERIVED
PMID: 30153638 (View on PubMed)

Other Identifiers

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2011-A00115-36

Identifier Type: OTHER

Identifier Source: secondary_id

NI10027 / AOM 10165

Identifier Type: -

Identifier Source: org_study_id