A Twelve Week, Open Label Extension Study in Patients With Schizophrenia

NCT ID: NCT01566162

Last Updated: 2019-04-09

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

191 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-04-30

Study Completion Date

2013-11-30

Brief Summary

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This is a 12-week, multi-center, open-label extension study designed to evaluate the longer-term safety, tolerability and effectiveness of lurasidone for the treatment of subjects with schizophrenia.

Detailed Description

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This is a 12-week, multi-center, open-label extension study designed to evaluate the longer-term safety, tolerability and effectiveness of lurasidone for the treatment of subjects with schizophrenia who have participated in Study D1050238, a double-blind, placebo-controlled, randomized withdrawal study of lurasidone for the maintenance treatment of subjects with schizophrenia. Subjects who have completed the 28-week double-blind phase or who have experienced a protocol-defined relapse event during the double-blind phase of study D1050238 will have the option to participate in this study. In addition, if/when the study is discontinued by the sponsor, all subjects participating in the open-label phase and the double-blind phase of study D1050238 will have the option to participate in this extension study

Conditions

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Schizophrenia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Lurasidone

Lurasidone 40 - 80mg flexible dose

Group Type EXPERIMENTAL

Lurasidone

Intervention Type DRUG

Lurasidone 40-80 mg taken orally taken once daily

Interventions

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Lurasidone

Lurasidone 40-80 mg taken orally taken once daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subject has agreed to participate by providing written informed consent.
* Subject will be eligible to participate if one of the following criteria is met:
* Subject has completed the 28-week double-blind phase of study D1050238
* Subject has experienced a protocol-defined relapse event during the double- blind phase in study D1050238
* Subject is participating in the open-label or double-blind phase of study D1050238 if/when study D1050238 is terminated by the sponsor.
* Subject has completed all required assessments on the final study visit (Study Visit Number 42) in study D1050238.
* Subject is judged by the Investigator to be suitable for participation in a 12-week clinical trial involving open-label lurasidone treatment and is able to comply with the protocol in the opinion of the Investigator.

Exclusion Criteria

* Subject is considered by the investigator to be at imminent risk of suicide or injury to self, others, or property.
* Subject answers "yes" to "Suicidal Ideation" item 4 (active suicidal ideation with some intent to act, without specific plan) or item 5 (active suicidal ideation with specific plan and intent) on the C-SSRS at the extension baseline visit (Study Visit Number 42 in study D1050238). Subjects who answer "yes" to this question must be referred by the Investigator for appropriate follow-up evaluation and treatment.
* Subject tests positive for drugs of abuse or is suspected of current alcohol abuse at the extension baseline visit (Study Visit Number 42 in study D1050238). In the event a subject tests positive for cannabinoids, the Investigator will evaluate the subject's ability to abstain from cannabis during the study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sumitomo Pharma America, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lurasidone Medical Director, MD

Role: STUDY_DIRECTOR

Sumitomo Pharma America, Inc.

Locations

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K and S Professional Research Services

Little Rock, Arkansas, United States

Site Status

Woodland International Research Inc.

Little Rock, Arkansas, United States

Site Status

Comprehensive Clinical Development Inc.

Cerritos, California, United States

Site Status

Diligent Clinical Trials

Downey, California, United States

Site Status

Synergy Clinical Research Center

Escondido, California, United States

Site Status

CNS Network

Garden Grove, California, United States

Site Status

AXIS Clinical Trials

Los Angeles, California, United States

Site Status

Synergy Clinical Research Center

National City, California, United States

Site Status

Excell Research, Inc.

Oceanside, California, United States

Site Status

CNRI-Los Angeles. LLC

Pico Rivera, California, United States

Site Status

California Neuropsychopharmacolgoy Clinical Research Insitute

San Diego, California, United States

Site Status

Neuropsychiatric Research Center of Orange County

Santa Ana, California, United States

Site Status

Collaborative Neuroscience Network

Torrance, California, United States

Site Status

Florida Clinical Research Center, LLC

Bradenton, Florida, United States

Site Status

Accurate Clinical Trials

Kissimmee, Florida, United States

Site Status

Galiz Research

Miami Springs, Florida, United States

Site Status

Medical Research Group of Central Florida

Orange City, Florida, United States

Site Status

Atlanta Center for Medical Research

Atlanta, Georgia, United States

Site Status

Comprehensive NeuroScience Inc.

Atlanta, Georgia, United States

Site Status

Lake Charles Clinical Trials, LLC

Lake Charles, Louisiana, United States

Site Status

Lousiana Clinical Research, LLC

Shreveport, Louisiana, United States

Site Status

Center for Behavioral Health, LLC

Rockville, Maryland, United States

Site Status

Psychiatric Care and Research Center

O'Fallon, Missouri, United States

Site Status

Psych Care Consultants Research

St Louis, Missouri, United States

Site Status

Robert Lynn Horne, MD

Las Vegas, Nevada, United States

Site Status

CRI Worldwide LLC

Willingboro, New Jersey, United States

Site Status

Erie County Medical Center, Corp

Buffalo, New York, United States

Site Status

Neurobehavioral Research Inc.

Cedarhurst, New York, United States

Site Status

Comprehensive Clinical Development, Inc

Fresh Meadows, New York, United States

Site Status

Finger Lakes Clinical Research

Rochester, New York, United States

Site Status

Oklahoma Clinical Research

Oklahoma City, Oklahoma, United States

Site Status

CRI Worldwide LLC at Kirkbride

Philadelphia, Pennsylvania, United States

Site Status

Lincoln Research

Lincoln, Rhode Island, United States

Site Status

Community Clinical Research, Inc.

Austin, Texas, United States

Site Status

FutureSearch Clinical Trials LP

Austin, Texas, United States

Site Status

FutureSearch Clinical Trials, LP

Dallas, Texas, United States

Site Status

Pillar Clinical Research, LLC

Dallas, Texas, United States

Site Status

Department of Psychiatry, University of Utah Health Sciences Center

Salt Lake City, Utah, United States

Site Status

Centre Hospitalier Spécialisé (CHS) du Jura - Centre Médico Psychiatrique (CMP)

Dole, , France

Site Status

Hôpital Chalucet, Centre hospitalier intercommunal de Toulon la Seyne sur mer (CHITS)

Toulon, , France

Site Status

Dipartimento Salute Mentale ASL 1

Massa, , Italy

Site Status

A.O.U. Santa Chiara, U.O di Psichiatria 1 building n.4

Pisa, , Italy

Site Status

Regional Government Institution (RGI) 'Lipetsk Regional Psychoneurology Hospital'

Lipetsk, , Russia

Site Status

Limited Liability Company (LLC) 'Research Center For Treatment and rehabilitation 'Phoenix'

Rostov-on-Don, , Russia

Site Status

St. Petersburg State Healthcare Institution (SPbSHI) "City Psychiatric Hospital #6"

Saint Peterburg, , Russia

Site Status

St. Petersburg State Budgetary Healthcare Institution 'City Psychoneurology Dispensary #7 (with In-Patient Department)', (SPb SBHI "CPNDD-7")

Saint Petersburg, , Russia

Site Status

St. Petersburg State Budgetary Healthcare Institution 'City Psychoneurology Dispensary #7 (with In-Patient Department)', (SPb SBHI "CPNDD-7"), at Daycare Facility #1

Saint Petersburg, , Russia

Site Status

St. Petersburg State Government Healthcare Institution "City Psychiatric Hospital #4" (St. Petersburg Insane Asylum Distributor)

Saint Petersburg, , Russia

Site Status

Military Medical Academy, Clnic for Psychiatry

Belgrade, , Serbia

Site Status

Institute of Mental Health

Dusica, , Serbia

Site Status

Clinical Centre Kragujevac, Clinic for psychiatry

Kragujevac, , Serbia

Site Status

Clinical Centre Nis, Clinic for mental health protection

Niš, , Serbia

Site Status

Specialized hospital for psychiatric diseases "Sveti Vracevi"

Novi Kneževac, , Serbia

Site Status

Clinical Centre Vojvodine, Clinic for Psychiatry

Novi Sad, , Serbia

Site Status

Nemocnica s poliklinikou v Prievidzi so sidlom v Bojniciach, Psychiatricke oddelenie

Bojnice, , Slovakia

Site Status

Psychiatricka ambulancia Mentum s.r.o.

Bratislava, , Slovakia

Site Status

Psychiatricka nemocnica Michalovce n.o.

Michalovce, , Slovakia

Site Status

PsychoLine s.r.o. Psychiatricka ambulancia

Rimavská Sobota, , Slovakia

Site Status

Nemocnica s poliklinikou sv Barbory Roznava a.s. Psychiatricke oddelenie

Rožňava, , Slovakia

Site Status

"Centrum zdravia R.B.K., spol. s.r.o.

Svidník, , Slovakia

Site Status

Cape Trial Centre

Tygervalley, Western Cape, South Africa

Site Status

Research Unit, Department of Psychiatry Free State Psychiatric Complex

Bloemfontein, , South Africa

Site Status

Denmar Hospital Consulting Rooms

Pretoria, , South Africa

Site Status

Countries

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United States France Italy Russia Serbia Slovakia South Africa

Other Identifiers

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2011-004790-90

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

D1050307

Identifier Type: -

Identifier Source: org_study_id

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