Study of the Environmental Factors Modulating Children Immune Response in Northern Senegal
NCT ID: NCT01545115
Last Updated: 2012-03-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
410 participants
OBSERVATIONAL
2008-10-31
2010-02-28
Brief Summary
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A cohort of 410 children aged 1 to 10 from 5 villages of the Senegal River Valley(Podor District) was followed-up for 18 months. During that period, 5 visits have been made to the villages to assess the immunological and nutritional status of the children.
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Detailed Description
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A cohort of 410 children aged 1 to 10 from 5 villages of the Senegal River Valley(Podor District) was followed-up for 18 months. During that period, 5 visits have been made to the villages to assess the immunological and nutritional status of the children (T1 (October 2008), T2 (January 2009), T3 (June 2009), T4 (October 2009) and T5 (January 2010)).
The project was approved by the National Ethics Committee of Senegal. Written individual informed consent was obtained from each participant's parent or legal guardian at the beginning of the survey, and at each visit child's and parent's approval was sought orally.
Capillary blood was collected from the finger tip of each child, using sterile single-use material.
Body temperature was measured by means of auricular thermometer at all visits. Anthropomorphic data were collected at visits T2, T3, T4 and T5.
A Hemocue photometer (HemoCue AB, Ängelholm, Sweden) was used to determine haemoglobin concentration on a blood drop at visits T3, T4 and T5.
At each visit, a questionnaire was filled in for every child. Information was collected on the date of birth family membership to asses if siblings or children living in the same house were in the cohort.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
1 Year
10 Years
ALL
Yes
Sponsors
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Institut Pasteur de Lille
OTHER
Institut de Recherche pour le Developpement, Senegal
OTHER
Institut de Recherche pour le Developpement
OTHER_GOV
University of Lille Nord de France
OTHER
Région Nord-Pas de Calais, France
OTHER
Centre d'Infection et d'Immunité de Lille
OTHER
Centre National de la Recherche Scientifique, France
OTHER
Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV
Biomedical Research Center EPLS
OTHER
Responsible Party
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Principal Investigators
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Franck Remoué, PhD
Role: STUDY_CHAIR
Biomedical Research Center EPLS
Emmanuel Hermann, PhD A. Pr.
Role: STUDY_DIRECTOR
Biomedical Research Center
Jean Biram Sarr, PhD
Role: PRINCIPAL_INVESTIGATOR
Biomedical Research Center EPLS
Lobna Gaayeb, VetMed
Role: PRINCIPAL_INVESTIGATOR
Biomedical Research Center EPLS
Locations
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Biomedical Research Center EPLS
Saint-Louis, Saint-Louis, Senegal
Countries
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References
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Ndiath MO, Sarr JB, Gaayeb L, Mazenot C, Sougoufara S, Konate L, Remoue F, Hermann E, Trape JF, Riveau G, Sokhna C. Low and seasonal malaria transmission in the middle Senegal River basin: identification and characteristics of Anopheles vectors. Parasit Vectors. 2012 Jan 23;5:21. doi: 10.1186/1756-3305-5-21.
Gaayeb L, Pincon C, Cames C, Sarr JB, Seck M, Schacht AM, Remoue F, Hermann E, Riveau G. Immune response to Bordetella pertussis is associated with season and undernutrition in Senegalese children. Vaccine. 2014 Jun 5;32(27):3431-7. doi: 10.1016/j.vaccine.2014.03.086. Epub 2014 Apr 14.
Related Links
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EPLS website
Other Identifiers
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EPLS08-JBS
Identifier Type: -
Identifier Source: org_study_id
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