Effect of Low Glycaemic Index Diet on Blood Glucose Control in Chinese Type 2 Diabetic Patients
NCT ID: NCT01542554
Last Updated: 2012-08-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
44 participants
INTERVENTIONAL
2012-03-31
2012-12-31
Brief Summary
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Detailed Description
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Hong Kong Chinese obtain most of their carbohydrate intake through consumption of rice or rice related foods, which are considered as having high GI value. In addition, it has been demonstrated that Asian have higher post-prandial rise in blood glucose than Caucasian after consuming the same amount of carbohydrate. When the above two factors add together, we expect our local type 2 diabetic patients are suffering from significant post-prandial hyperglycaemia, which in turn translate into elevated 24-hour hyperglycaemia and A1c.
However, nearly all studies about glycaemic index and diabetes are conducted in Caucasian. It is unclear about the benefit in Chinese patients with type 2 diabetes who are currently having diet with high GI value.
We therefore hypothesized that low GI diet may improve blood glucose control in Chinese type 2 diabetic patients. To test this hypothesis, we plan to conduct this randomized controlled trial about low GI diet in Chinese diabetic patients.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Low glycaemic index diet
Low glycaemic index diet
Diabetic subjects will be given dietary advice with emphasis on low glycaemic index diet
Usual diabetic diet
Usual diabetic diet
Diabetic subjects will be given dietary advice without mention about glycaemic index
Interventions
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Low glycaemic index diet
Diabetic subjects will be given dietary advice with emphasis on low glycaemic index diet
Usual diabetic diet
Diabetic subjects will be given dietary advice without mention about glycaemic index
Eligibility Criteria
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Inclusion Criteria
2. Already performing self monitoring blood glucose ( SMBG ) with pre- and post-meal readings.
3. At least 50% of 2hr post-meal capillary blood glucose values are \> 9 mmol/L.
4. A1c between 7.0 to 8.0% within 2 weeks of randomization.
5. Next follow-up is scheduled to at least 12 weeks or more if currently follow-up in TWEH.
6. On stable dose of anti-diabetic drug in the preceding 10 weeks.
7. No change in anti-DM drug in the next 10 week.
8. At least 18 years old.
9. Can read and understand consent form written in Chinese.
10. Can give informed consent.
Exclusion Criteria
2. Using rapid onset insulin ( such as Humalog, Novorapid, Actrapid HM, Mixtard HM, Novomix and Humalog Mix ).
3. Using acarbose.
4. Anaemia.
5. Known thalassaemia.
6. Suspected or confirmed iron deficiency.
7. On warfarin.
8. Renal impairment with serum creatinine \> 150 umol/L
9. Active medical illness, such as hepatitis, malignancy, infection, inflammatory arthritis, etc.
10. Unable to follow low glycaemic index diet.
11. Currently participate in other study.
12. Mentally or cognitively disable.
13. Pregnant or lactating women.
14. Hospital Authority or TWEH staff.
18 Years
ALL
No
Sponsors
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Hospital Authority, Hong Kong
OTHER_GOV
Responsible Party
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Ace Lee
Doctor
Principal Investigators
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Ace Lee, MBBS
Role: PRINCIPAL_INVESTIGATOR
Department of Medicine and Rehabilitation, Tung Wah Eastern Hospital, Hospital Authority, Hong Kong
Locations
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Tung Wah Eastern Hospital, Hospital Authority
Hong Kong SAR, Hong Kong SAR, China
Countries
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Central Contacts
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Facility Contacts
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Ace Lee, MBBS
Role: primary
References
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Brand-Miller J, Hayne S, Petocz P, Colagiuri S. Low-glycemic index diets in the management of diabetes: a meta-analysis of randomized controlled trials. Diabetes Care. 2003 Aug;26(8):2261-7. doi: 10.2337/diacare.26.8.2261.
Miller JB, Pang E, Bramall L. Rice: a high or low glycemic index food? Am J Clin Nutr. 1992 Dec;56(6):1034-6. doi: 10.1093/ajcn/56.6.1034.
Venn BS, Williams SM, Mann JI. Comparison of postprandial glycaemia in Asians and Caucasians. Diabet Med. 2010 Oct;27(10):1205-8. doi: 10.1111/j.1464-5491.2010.03069.x.
Jenkins DJ, Kendall CW, McKeown-Eyssen G, Josse RG, Silverberg J, Booth GL, Vidgen E, Josse AR, Nguyen TH, Corrigan S, Banach MS, Ares S, Mitchell S, Emam A, Augustin LS, Parker TL, Leiter LA. Effect of a low-glycemic index or a high-cereal fiber diet on type 2 diabetes: a randomized trial. JAMA. 2008 Dec 17;300(23):2742-53. doi: 10.1001/jama.2008.808.
Other Identifiers
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HKEC-2011-080
Identifier Type: -
Identifier Source: org_study_id