Typical Daily Experiences, Ischemia and Repolarization in Coronary Artery Disease
NCT ID: NCT01531231
Last Updated: 2024-12-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
301 participants
OBSERVATIONAL
2011-06-02
2016-03-29
Brief Summary
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Detailed Description
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In this study we propose to test the following in patients with CAD:
* Determine whether experiences assessed randomly throughout the day are associated with changes in the blood supply to your heart muscle as measured by electrical recordings from your chest.
* Determine whether typical daily experiences are associated with changes in the recovery time portion of your heart beat cycle as measured by electrical recordings from your chest.
* Determine whether changes in the recovery time portion of your heart beat cycle associated with typical daily experiences occur exclusively with changes in the blood supply to your heart muscle.
* Determine whether typical daily experiences influences blood supply and recovery time based on the severity and presence of CAD (when comparing CAD patients to healthy subjects).
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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YOUNG HEALTHY NO CORONARY ARTERY DISEASE
\- Whether an association between typical daily experiences and recovery time varies with age; this group will be compared to the older comparison group and to previous data collected from those subjects who participated in the Long QT Syndrome study (LQTS).
No interventions assigned to this group
OLDER HEALTHY NO CORONARY ARTERY DISEASE
\- Determine whether daily emotion influences ischemia and repolarization differentially as a function of the severity of CAD and presence of CAD when comparing CAD patients with healthy patients
No interventions assigned to this group
HIGH RISK CORONARY ARTERY DISEASE (CAD)
\- Determine whether emotion assessed randomly throughout the day is associated with myocardial ischemia
No interventions assigned to this group
LOW RISK CORONARY ARTERY DISEASE (CAD)
\- Determine whether typical daily emotion influences ischemia and repolarization differentially as a function of the severity of CAD and presence of CAD
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* At least 21 years of age or older
* Stable coronary artery disease
* Willing to participant in 3 days of Holter monitor recordings and respond to surveys on a study provided smartphone
* Proficient in English
* 21 years of age or older
* Have stable coronary artery disease with a documented previous myocardial infarction
* Recent ECHO, MUGA or angiography (\< 5year old) reflecting a left-ventricular ejection fraction \<35%
* Single or dual chamber ICD, with a back up rate of ventricular pacing at \< 45 bpm
* Willing to wear a Holter monitor for 3 days and respond to surveys on a study provided smartphone
* Proficient in English
* 51 years of age or older
* No history and evidence of ischemic heart disease
* Normal screening ECG without evidence for rhythm abnormalities, conduction abnormalities, hypertrophy, or other pathologies
* Age matched within 5 years to CAD patients
* Negative treadmill/bicycle exercise test
* Willing to wear a Holter monitor for 3 days and respond to surveys on a study provided smartphone
* Proficient in English
* 21 to 50 years of age
* Normal screening ECG without evidence for rhythm abnormalities, conduction abnormalities, hypertrophy, or other pathologies
* Willing to wear a Holter monitor for 3 days and respond to surveys on a study provided smartphone
Exclusion Criteria
* An implanted cardiac resynchronization pacemaker with ICD (CRT-D)
* Heart rhythm artificially continuously paced
* Presence of a bundle branch block evident on any ECG
* History of ischemic heart disease (CAD),prior myocardial infarction
* History of cardiac disease
* History of ischemic heart disease (CAD), prior myocardial infarction
* History of cardiac diseases
* Abnormal ECG
21 Years
ALL
Yes
Sponsors
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University of Rochester
OTHER
Richard Lane
OTHER
Responsible Party
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Richard Lane
MD, PhD
Principal Investigators
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Richard D Lane, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Arizona
Locations
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University of Arizona
Tucson, Arizona, United States
Countries
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Other Identifiers
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