Treatment of Extended Spectrum Betalactamase Producing Bacteria Causing Urinary Tract Infections in General Practice

NCT ID: NCT01531023

Last Updated: 2016-10-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

168 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-04-30

Study Completion Date

2016-09-30

Brief Summary

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The prevalence of extended spectrum beta-lactamase (ESBL) producing bacteria found in urine sample cultures has been increasing over the past decades.

The study hypothesis is to assess the clinical and microbiological outcome of pivmecillinam treatment of ESBL producing E. coli and K. Pneumoni, as well as to observe the clinical and microbiological outcome of the same group of bacteria treated with other antiinfectious agents.

Samples are gathered in primary care setting.

Detailed Description

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Conditions

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Urinary Tract Infections

Keywords

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Extended-Spectrum Beta-lactamase Producing Bacteria

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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ESBL producing E. coli bacteria

Group of patients with identified ESBL producing E.coli in a urine sample taken in a primary care setting.

No interventions assigned to this group

Non-ESBL E.coli urinary tract infection

E.coli bacteria found in the setting of a urinary tract infection in a primary care setting where ESBL producing bacteria are not found.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

\- All patients were urinary sample taken in a primary care setting shows significant growth of ESBL producing E. coli.

Above age 16.

Exclusion Criteria

\- Sample from patients in hospital care or living in nursing home facilities. Inability to understand and sign information leaflet.
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital of North Norway

OTHER

Sponsor Role collaborator

St. Olavs Hospital

OTHER

Sponsor Role collaborator

Helse Stavanger HF

OTHER_GOV

Sponsor Role collaborator

The Hospital of Vestfold

OTHER

Sponsor Role collaborator

Vestre Viken Hospital Trust

OTHER

Sponsor Role collaborator

University Hospital, Akershus

OTHER

Sponsor Role collaborator

Unilabs

UNKNOWN

Sponsor Role collaborator

University of Oslo

OTHER

Sponsor Role lead

Responsible Party

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Marianne Bollestad

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Morten Lindbaek, Md PhD

Role: STUDY_DIRECTOR

University of Oslo

Locations

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Vestre Viken Hospital Trust

Bærum, , Norway

Site Status

University Hospital Akershus

Lørenskog, , Norway

Site Status

Unilabs

Skien, , Norway

Site Status

Helse Stavanger HF

Stavanger, , Norway

Site Status

University Hospital of North Norway

Tromsø, , Norway

Site Status

St Olavs Hospital

Trondheim, , Norway

Site Status

Vestfold Hospital Trust

Tønsberg, , Norway

Site Status

Countries

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Norway

References

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Bollestad M, Grude N, Solhaug S, Raffelsberger N, Handal N, Nilsen HS, Romstad MR, Emmert A, Tveten Y, Soraas A, Jenum PA, Jenum S, Moller-Stray J, Weme ET, Lindbaek M, Simonsen GS; (the Norwegian ESBL UTI study group). Clinical and bacteriological efficacy of pivmecillinam treatment for uncomplicated urinary tract infections caused by ESBL-producing Escherichia coli: a prospective, multicentre, observational cohort study. J Antimicrob Chemother. 2018 Sep 1;73(9):2503-2509. doi: 10.1093/jac/dky230.

Reference Type DERIVED
PMID: 29982514 (View on PubMed)

Other Identifiers

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2011/2214-3

Identifier Type: -

Identifier Source: org_study_id