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Trial Outcomes & Findings for PharmacoMRI of Parkinson Disease (NCT NCT01528592)

NCT ID: NCT01528592

Last Updated: 2018-05-03

Results Overview

Correlation coefficient between UPDRS III score and independent components analysis network strength in left parietal cortex. UPDRS III is the Unified Parkinson's Disease Rating Scale composite motor score.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

18 participants

Primary outcome timeframe

1 hour

Results posted on

2018-05-03

Participant Flow

Recruitment period: 12/1/2011 - 4/30/2012 Location: Medical clinic in Chicago

Participant milestones

Participant milestones
Measure
On / Off Medication
Subjects undergo MRI scanning in the medication off state and 1 hour after receiving medications.
Overall Study
STARTED
18
Overall Study
COMPLETED
18
Overall Study
NOT COMPLETED
0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

PharmacoMRI of Parkinson Disease

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
On / Off Medication
n=18 Participants
Subjects undergo MRI scanning in the medication off state and 1 hour after receiving medications.
Age, Categorical
<=18 years
0 Participants
n=5 Participants
Age, Categorical
Between 18 and 65 years
11 Participants
n=5 Participants
Age, Categorical
>=65 years
7 Participants
n=5 Participants
Age, Continuous
66.22 years
STANDARD_DEVIATION 8.71 • n=5 Participants
Sex: Female, Male
Female
3 Participants
n=5 Participants
Sex: Female, Male
Male
15 Participants
n=5 Participants
Region of Enrollment
United States
18 participants
n=5 Participants

PRIMARY outcome

Timeframe: 1 hour

Correlation coefficient between UPDRS III score and independent components analysis network strength in left parietal cortex. UPDRS III is the Unified Parkinson's Disease Rating Scale composite motor score.

Outcome measures

Outcome measures
Measure
On / Off Medication
n=15 Participants
Subjects undergo MRI scanning in the medication off state and 1 hour after receiving medications.
Correlation Coefficient Between UPDRS III Score and Independent Components Analysis Network Strength in Left Parietal Cortex.
0.5869 unitless

Adverse Events

On / Off Medication

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Darren Gitelman, MD

Northwestern University

Phone: 312-908-8266

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place