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Low Dose Effects of X-rays in Pediatric Patients Undergoing a CT Examination.

NCT ID: NCT01518673

Last Updated: 2021-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

140 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-02-29

Study Completion Date

2015-06-30

Brief Summary

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Patients undergoing a computed tomography are exposed to a relatively high dose of X-rays. Pediatric patients are known to be very radiosensitive with respect to radiation induced cancer. Using the technique of scoring γ-H2AX foci in peripheral blood lymphocytes the most important lesions to the genetic material DNA, double strand breaks induced by CT X-rays can be detected. The technique will be applied in a multicenter setting for evaluation of X-effects induced by a computed tomography examination in a population of pediatric patients. To this end a blood sample will be taken from the patients before and after the examination.

Detailed Description

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Conditions

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Pediatric Patients Undergoing a Computed Tomography Examination

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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X-rays

Blood test

Intervention Type PROCEDURE

Analysing X-ray induced genetic effects in pediatric patients directly after a computer tomography scan.

Interventions

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Blood test

Analysing X-ray induced genetic effects in pediatric patients directly after a computer tomography scan.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* pediatric patients wearing a catheter
Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Federal Agency for Nuclear Control, Belgium

OTHER_GOV

Sponsor Role collaborator

University Ghent

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter Smeets, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Ghent

Locations

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University Hospital Ghent

Ghent, , Belgium

Site Status

Countries

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Belgium

Related Links

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http://www.uzgent.be

Related Info

Other Identifiers

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2010/708

Identifier Type: -

Identifier Source: org_study_id