Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk

NCT ID: NCT01514539

Last Updated: 2015-01-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 44 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-08-31
• Study Completion Date: 2014-04-30

Brief Summary

Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk Studies suggest that childbearing is an important contributor to the development of obesity in many women and that breastfeeding may be protective.

Ghrelin and peptide YY (PYY) are gut hormones involved in appetite regulation and energy homeostasis and are biological neuroendocrine signals that potentially affect body weight and adiposity/

Detailed Description

Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk.

This study evaluated whether fasting or postprandial ghrelin or PYY is different between lactating and nonlactating postpartum women matched for age, body weight, and adiposity.

Eligibility Criteria: Healthy females, 18+ years old, non-smokers, no major food allergies, first-time mom, currently pregnant or within 1 month of giving birth.

Conditions

Maternal Obesity Syndrome

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Four weeks Postpartum Lactating

women between 18 and 45 who delivered their first child 4 weeks prior and who were currently lactating and planning to lactate for one year postpartum.

Group Type: OTHER

cross-sectional

Intervention Type: OTHER

Monitoring two recently discovered appetite hormones called "ghrelin" and "neuropeptide YY (PYY)." This study evaluated whether fasting or postprandial ghrelin or PYY is different btween lactating and nonlactating postpartum women matched for age, body weight, and adiposity.

Control Never Pregnant

women between 18 and 45 who have never been pregnant

Group Type: OTHER

cross-sectional

Intervention Type: OTHER

Monitoring two recently discovered appetite hormones called "ghrelin" and "neuropeptide YY (PYY)." This study evaluated whether fasting or postprandial ghrelin or PYY is different btween lactating and nonlactating postpartum women matched for age, body weight, and adiposity.

Interventions

cross-sectional

Monitoring two recently discovered appetite hormones called "ghrelin" and "neuropeptide YY (PYY)." This study evaluated whether fasting or postprandial ghrelin or PYY is different btween lactating and nonlactating postpartum women matched for age, body weight, and adiposity.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy women (non-smokers) at least 18 years old who did not have any pregnancy complications, and gave birth to their first child within one month.
• The study is open to women who are breastfeeding or formula feeding.

Exclusion Criteria

• Smoker,
• had twins or triples,
• had any major complication of pregnancy(example,
• gestational diabetes);
• have kidney, liver, hormonal, stomach, intestine,lung, heart or blood disease. This also includes high blood pressure;
• use prescription or over-the-counter medicine or herbal drinks or pills.
• History of depression, anxiety, disordered eating, other psychological problems, alcoholism or other substance abuse.
• Severely claustrophobic.
• Having a strong fear of needles and/or do not feel you can have blood drawn every 30 minutes from a plastic catheter.
• Are not able to or willing to fully participate in the study, and are pregnant, anemic or have a thyroid problem.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Wyoming

OTHER

Sponsor Role: lead

Responsible Party

Enette Larson-Meyer

Phd, RD, FACSM

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Dawine E. Larson-Meyer, Phd, RD

Role: PRINCIPAL_INVESTIGATOR

University of Wyoming

Locations

Nutritional and Exercise Lab University of Wyoming

Laramie, Wyoming, United States

Countries

United States

Other Identifiers

P20RR016474

Identifier Type: NIH

Identifier Source: org_study_id

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