Brain-imaging and Adolescent Neuroscience Consortium

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2012-09-30

Study Completion Date

2017-09-30

Brief Summary

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This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.

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Detailed Description

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The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.

Conditions

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Alcohol Abuse

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Alcohol-naive adolescents

A general population longitudinal cohort of alcohol-naïve (or h/o minimal recent-onset drinking) adolescents in three specific age-groups: early (12-14 y/o), middle (15-17 y/o), and late (18-21 y/o).

No interventions assigned to this group

Treatment sample

A sample of adolescents who have a \>1 year history of heavy drinking but have agreed to stop drinking as part of their treatment plan

No interventions assigned to this group

High risk sample

High-risk adolescents who have a family history of alcohol-use disorder and other risk factors (symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), Conduct Disorder, or Mood Disorder)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* able to read and understand English
* available for follow-up
* parental consent/adolescent assent for those 12-17 years
* consent for those 18-21 years

Exclusion Criteria

* Weight \> 300 lbs
* braces or unremovable embedded metal
* claustrophobia or inability to lie still in MRI machine
* current or past 12-mos pregnancy (females)
* requires urgent medical/mental health care

Minimum Eligible Age

12 Years

Maximum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No