Probiotics in Respiratory Tract Infections in Children

NCT ID: NCT01510938

Last Updated: 2013-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

242 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-01-31

Study Completion Date

2012-12-31

Brief Summary

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The purpose of this study is to assess the potential of probiotics in prevention of respiratory tract infections and their complications in children

Detailed Description

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Conditions

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Infections, Respiratory Tract

Keywords

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Children Respiratory Tract Infections Prevention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Placebo

1 g of rice maltodextrin will be reconstituted in 25-50 ml of tepid water or juice and immediately fed once a day for 2-weeks trial period or to the end of acute respiratory infection depending on whatever is longer.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

1 g in 25-50 ml of tepid water or juice fed once a day for 2-weeks trial period or to the end of acute respiratory infection depending on whatever is longer.

Probiotic

powder of L. acidophilus DDS-1, B. lactis UABLA-12, 50 mg of fructooligosaccharide

1 g of probiotic will be reconstituted in 25-50 ml tepid water or juice and immediately fed once a day (5 billion CFU/daily) for 2-weeks trial period or to the end of acute respiratory infection depending on whatever is longer.

Group Type EXPERIMENTAL

L. acidophilus DDS-1, B. lactis UABLA-12

Intervention Type DIETARY_SUPPLEMENT

1 g of probiotic will be reconstituted in 25-50 ml tepid water, juice or age specific baby food and immediately fed once a day (5 billion CFU/daily) for 2-weeks trial period or to the end of acute respiratory infection depending on whatever is longer.

Interventions

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L. acidophilus DDS-1, B. lactis UABLA-12

1 g of probiotic will be reconstituted in 25-50 ml tepid water, juice or age specific baby food and immediately fed once a day (5 billion CFU/daily) for 2-weeks trial period or to the end of acute respiratory infection depending on whatever is longer.

Intervention Type DIETARY_SUPPLEMENT

Placebo

1 g in 25-50 ml of tepid water or juice fed once a day for 2-weeks trial period or to the end of acute respiratory infection depending on whatever is longer.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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DDS-Junior Rice maltodextrin

Eligibility Criteria

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Inclusion Criteria

* Age 3-12 yrs
* At least one episode of respiratory tract infection in the previous epidemiological season
* Direct telephone access available
* Informed consent signed

Exclusion Criteria

* Vaccination against the influenza
* Chronic adeno-tonsillar pathology
* Recurrent otitis
* Sinusitis
* Respiratory allergy
* Acute or chronic intestinal disease with diarrhea and/or malabsorption syndrome
* Lactose intolerance
* Functional or organic constipation
* Down syndrome
* Congenital or acquired heart disease
* Cerebral palsy
* Any chronic hepatic, renal, metabolic, or immune system disease
Minimum Eligible Age

3 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Lviv National Medical University

OTHER

Sponsor Role lead

Responsible Party

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Sergei V. Gerasimov, MD, PhD

Associate Professor of Pediatrics

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sergei V Gerasimov, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Lviv National Medical University

Locations

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Lviv City Children Hospital

Lviv, Lviv Oblast, Ukraine

Site Status

Countries

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Ukraine

Other Identifiers

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SG-11009

Identifier Type: -

Identifier Source: org_study_id