The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis
NCT ID: NCT01507766
Last Updated: 2012-11-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
60 participants
INTERVENTIONAL
2010-09-30
2011-09-30
Brief Summary
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However, the role of EEN is considered to be influenced by intra-abdominal hypertension (IAH) in patients with SAP. The previous studies showed that gut was the most sensitive splanchnic organ to the increase of intra-abdominal pressure (IAP). When IAH occurs, it reduces the blood flow of gut, and then results in the development of intestinal ischemia and edema. The hypoxia and hypoperfusion of intestine leads to the increase of permeability of the intestinal mucosal barrier, and then leads to bacterial translocation. Therefore, IAH could result in the gastrointestinal dysfunction. Nevertheless, the different impacts of specific IAP values on the tolerance of EEN have not been reported.
Furthermore, the effects of early enteral feeding on the IAP in SAP also remain unknown. Due to the severe inflammatory response of SAP, could EEN increase the burden of bowel, cause expansion of intestinal cavity, thus increase IAP? However, there were rare literatures up to date reporting the association between EEN and IAH in patients with SAP. Therefore, the present study aimed to investigate the influence of specific IAP on the tolerance of early enteral feeding, as well as the effects of EEN on IAP in SAP patients. Moreover, the impacts of EEN on the disease severity and clinical outcome of SAP were also researched.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Early enteral nutrition
The enteral nutrition was started within 48h after admission
early enteral nutrition
The enteral nutrition was started within 48h after admission
Delayed enteral nutrition
The enteral nutrition was started at the 8th day after admission
Delayed enteral nutrition
The enteral nutrition was started at the 8th day after admission
Interventions
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early enteral nutrition
The enteral nutrition was started within 48h after admission
Delayed enteral nutrition
The enteral nutrition was started at the 8th day after admission
Eligibility Criteria
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Inclusion Criteria
* Within 3 days from the onset of the disease
* Hemodynamics stable
Exclusion Criteria
* Ileus of lower digestive tract
* Pregnant pancreatitis
* Chronic organs dysfunction
* Immunodeficiency
18 Years
70 Years
ALL
No
Sponsors
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Jinling Hospital, China
OTHER
Nanjing University School of Medicine
OTHER
Responsible Party
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Jiakui Sun
Principal Investigator
Principal Investigators
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Wei-qin Li, M.D.
Role: STUDY_DIRECTOR
Jinlin Hospital
Locations
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Department of SICU, Research Institute of General Surgery , Jinling Hospital
Nanjing, Jiangsu, China
Countries
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References
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Sun JK, Li WQ, Ke L, Tong ZH, Ni HB, Li G, Zhang LY, Nie Y, Wang XY, Ye XH, Li N, Li JS. Early enteral nutrition prevents intra-abdominal hypertension and reduces the severity of severe acute pancreatitis compared with delayed enteral nutrition: a prospective pilot study. World J Surg. 2013 Sep;37(9):2053-60. doi: 10.1007/s00268-013-2087-5.
Sun JK, Mu XW, Li WQ, Tong ZH, Li J, Zheng SY. Effects of early enteral nutrition on immune function of severe acute pancreatitis patients. World J Gastroenterol. 2013 Feb 14;19(6):917-22. doi: 10.3748/wjg.v19.i6.917.
Other Identifiers
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110-85
Identifier Type: -
Identifier Source: org_study_id