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Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism

NCT ID: NCT01503645

Last Updated: 2012-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-05-31

Brief Summary

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1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA).
2. AA may form AA-DNA adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer
3. Different enzymes have been reported to detoxify plant alkaloids or other components. Genes that regulate the production of these metabolic enzymes may affect the chance of CHN.
4. By comparing the differences in the polymorphisms of these genes between patient with CHN and control, we may find the changes that play a significant genetic factors for CHN.

Detailed Description

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Conditions

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Kidney Diseases

Keywords

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kidney diseases drugs, Chinese herbal aristolochic acid polymorphism, genetic

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Patient with suspected Chinese herb nephropathy, and their family Control group match for sex age and geographic area (with or without herabla use)
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Department of Health, Executive Yuan, R.O.C. (Taiwan)

OTHER_GOV

Sponsor Role collaborator

National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kwan-Dun Wu, MD, PhD

Role: STUDY_CHAIR

National Taiwan University Hospital

Locations

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Far Estern Memorial Hospital

Banqiao District, Taipei, Taiwan

Site Status NOT_YET_RECRUITING

National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Fe-Lin L Wu, Ph.D.

Role: CONTACT

Phone: +886-2-23938231

Email: [email protected]

Kwan-Dun Wu, MD, Ph.D.

Role: CONTACT

Phone: +886-2-23123456

Email: [email protected]

Facility Contacts

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Kwan-Dun Wu, MD, PhD

Role: primary

Other Identifiers

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95D010

Identifier Type: -

Identifier Source: secondary_id

9461701139

Identifier Type: -

Identifier Source: org_study_id