Service Member Fatigue and Lack of Motivation Following Concussion
NCT ID: NCT01496586
Last Updated: 2019-12-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
45 participants
OBSERVATIONAL
2011-12-01
2015-08-03
Brief Summary
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\- Many service members have reported feeling tired, a loss of motivation, mood changes, and problems working with others after they have a concussion during deployment. These problems may lead to problems with their job and relationships. This study hopes to figure out what parts of the brain may be affected in people with these problems after a concussion.
Objectives:
\- To learn more about the problems that may occur after service members have a concussion during deployment and return home.
Eligibility:
* Service members or veterans between 18 and 40 years of age who have had a mild traumatic brain injury (concussion) in the past 6 months.
* Companions (at least 18 years of age) of the service members will also be included in this study. Companions will have interacted with the service member at least 1 hour a week since deployment.
Design:
* Service members will have 1 week of tests at the National Institutes of Health Clinical Center. Companions will have 2 days of tests at the Center.
* Each day, service members will have 4 or 8 hours of tests. Tests will include a medical history and physical exam, neuropsychological tests and imaging studies. The tests will ask about fatigue, stress, mood, pain, daily activities, and family support. The imaging studies will measure brain function at rest and during activity.
* Companions will have a medical history and physical exam. They will also complete several questionnaires about themselves as well as the service member/veteran. The tests will ask about fatigue, stress, mood, pain, daily activities, and family support....
Detailed Description
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Study Design: Observational, natural history study.
Populations: 1) Individuals who have sustained a mild traumatic brain injury as a service member deployed in support of Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn, and who continue to experience symptoms more than 6 months after injury, and 2) Companions of individuals from the first group.
Outcome Measures: We will seek statistical associations between fatigue measures and brain morphometric and white matter diffusion measurements obtained by MRI as well as task and resting state fMRI.
Conditions
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Keywords
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Study Design
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COHORT
CROSS_SECTIONAL
Eligibility Criteria
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Inclusion Criteria
* At least six months from time of injury;
* Age range 18 or older;
* A self-report of somatic or behavioral symptoms that developed within 3 months following mTBI and were not present before injury, and may or may not be present at enrollment:
* Easy fatiguability
* Sleep disturbance
* Headache or other chronic widespread pain that does not seem related to extremity injury
* Emotional lability
* Lack of spontaneity or apathy
* Lack of motivation
* Feelings of anxiety
* Personality change that they or others have noticed
* Irritability or aggressiveness
* The mTBI participant provides informed consent.
* Chosen by a mTBI participant as a close companion (i.e, spends or in the last 3 years has spent a minimum of 1 hour per week on average with the mTBI participant and with whom the mTBI participant is comfortable discussing personal matters);
* The companion provides informed consent.
Exclusion Criteria
* Diagnosis of sleep apnea, thyroid disorder, or rheumatoid arthritis
* Any history of head injury associated with a loss of consciousness that lasted longer than 24 hours (not including sedation);
* Daily use of more than 600mg caffeine (equivalent to approximately five cups of coffee).
* Headaches more than once a month prior to deployment;
* Pregnancy;
* Claustrophia;
* Inability to comfortably lie supine for two hours
-Lack of understanding of the English language
18 Years
ALL
No
Sponsors
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National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Responsible Party
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Principal Investigators
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Eric M Wassermann, M.D.
Role: PRINCIPAL_INVESTIGATOR
National Institute of Neurological Disorders and Stroke (NINDS)
Locations
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National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
Countries
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References
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Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA. Mild traumatic brain injury in U.S. Soldiers returning from Iraq. N Engl J Med. 2008 Jan 31;358(5):453-63. doi: 10.1056/NEJMoa072972. Epub 2008 Jan 30.
Jones E, Fear NT, Wessely S. Shell shock and mild traumatic brain injury: a historical review. Am J Psychiatry. 2007 Nov;164(11):1641-5. doi: 10.1176/appi.ajp.2007.07071180.
Jones E, Hodgins-Vermaas R, McCartney H, Everitt B, Beech C, Poynter D, Palmer I, Hyams K, Wessely S. Post-combat syndromes from the Boer war to the Gulf war: a cluster analysis of their nature and attribution. BMJ. 2002 Feb 9;324(7333):321-4. doi: 10.1136/bmj.324.7333.321.
Other Identifiers
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12-N-0030
Identifier Type: -
Identifier Source: secondary_id
120030
Identifier Type: -
Identifier Source: org_study_id