Effects of Vitamin A and Carotenoids on Iron Absorption

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2012-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The objective of this study is to investigate the effect of vitamin A and carotenoids on iron absorption in healthy subjects with low and normal vitamin A status. Vitamin A and carotenoids have been reported to enhance the nonheme iron absorption, but the results from human isotope studies are equivocal. Radio-iron studies in Venezuelan adults have consistently reported an increase in iron absorption, whereas stable and radio isotopes studies conducted in Sweden and Switzerland reported no influence. Differences in vitamin A status of the subjects may be a possible explanation for the contradictory findings. In this study, iron absorption will be measured from an iron-fortified maize bread meal with or without retinyl palmitate or β-carotene by using both stable- and radioactive-isotope techniques in Venezuelan women with a range of vitamin A status.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Vitamin A Supplementation on Iron Metabolic Homeostasis of Preschool Children in Sichuan,China

NCT01355263

Iron Metabolic Homeostasis

COMPLETED NA

Vitamin A Equivalence of Plant Carotenoids in Children

NCT00680212

Vitamin A Deficiency

COMPLETED PHASE2

Effect of Chitin and Ascorbic Acid on Dietary Insect Iron Absorption

NCT06822062

Iron Deficiency (Without Anemia)

RECRUITING NA

A Pilot Study to Assess the Influence of Dietary Organic Acids on Iron Absorption.

NCT01991600

Iron Deficiency Anaemia

COMPLETED EARLY_PHASE1

Meals to Improve Absorption of Iron Supplements

NCT04793906

Iron-deficiency Iron Deficiency Anemia Iron Deficiency Anemia Treatment

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Iron Absorption

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Retinyl palmitate

Labeled iron as FeSO4 (4 mg) added to a test meal with or without retinyl palmitate (1000 RE)

Group Type OTHER

Labeled iron solutions

Intervention Type OTHER

Labeled iron as FeSO4 (4 mg/test meal)

Beta-carotene

Labeled iron as FeSO4 (4 mg) added to a test meal with or without beta-carotene (1000 RE)

Group Type OTHER

Labeled iron solutions

Intervention Type OTHER

Labeled iron as FeSO4 (4 mg/test meal)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Labeled iron solutions

Labeled iron as FeSO4 (4 mg/test meal)

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Women 18-52 years old
* Body weight ≤ 70 kg
* Body mass index (BMI), 18.5-30 kg/m2
* Adequate vitamin A status (SR ≥ 0.7 μmol/L, n=20)
* Inadequate vitamin A status (SR \< 0.7 μmol/L, n=20)
* No major medical illnesses (no known infection, gastrointestinal or metabolic disorders)

Exclusion Criteria

* Pregnancy or lactation
* Regular intake of medication (except oral contraceptives)
* Blood donation or significant blood loss (accident, surgery) over the past 4 months
* Currently participating in another clinical trial or having participated in another clinical trial during the last 3 months prior to the beginning of this study
* Former participation in a study involving administration of iron stable isotopes

Minimum Eligible Age

18 Years

Maximum Eligible Age

52 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes