Efficacy and Tolerance of a Follow-On Formula Fed to Children From 36-48 Months of Age

NCT ID: NCT01488435

Last Updated: 2012-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

310 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-11-30

Study Completion Date

2012-06-30

Brief Summary

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The purpose is to determine if the consumption of study product has an effect on acute respiratory infections and/or diarrheal disease.

Detailed Description

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Conditions

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Acute Respiratory Infection Diarrheal Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Cow's Milk

Powdered whole cow's milk

Group Type PLACEBO_COMPARATOR

Cow's milk

Intervention Type DIETARY_SUPPLEMENT

Powdered whole cow's milk

Follow-On Formula

Powdered Follow-On Formula with added long-chain Polyunsaturated fatty acid, prebiotics, and polysaccharide

Group Type EXPERIMENTAL

Follow-On Formula

Intervention Type DIETARY_SUPPLEMENT

Powdered Follow-On Formula with added long-chain Polyunsaturated fatty acid, prebiotics, and polysaccharide

Interventions

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Cow's milk

Powdered whole cow's milk

Intervention Type DIETARY_SUPPLEMENT

Follow-On Formula

Powdered Follow-On Formula with added long-chain Polyunsaturated fatty acid, prebiotics, and polysaccharide

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Child 36-48 months of age
* Child is currently attending a daycare and has attended for 6 months or less
* Has consumed cow's milk or a cow's milk-based beverage during the 48 hours prior to randomization
* Signed informed consent

Exclusion Criteria

* Child who received any food product or supplement containing probiotics or prebiotics in the 15 days prior to randomization
* Child with allergy to gluten or serious concurrent illness that will interfere in the general management of the child
* Child with diarrhea or acute respiratory infection during the 48 hours prior to randomization
* Child's z-score of weight for height \< -3 according to World Health Organization criteria
Minimum Eligible Age

36 Months

Maximum Eligible Age

48 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shanghai Children's Medical Center

OTHER

Sponsor Role collaborator

Shanghai, China

UNKNOWN

Sponsor Role collaborator

Mead Johnson Nutrition

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Xingming Jin, M.D.

Role: PRINCIPAL_INVESTIGATOR

Professor of Development and Behavioral Pediatrics, Shanghai Children Medical Center

Locations

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Shi-ji-xing Child Care Center, Jin Dong District

Jinhua, Zhejiang, China

Site Status

Countries

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China

References

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Li F, Jin X, Liu B, Zhuang W, Scalabrin D. Follow-up formula consumption in 3- to 4-year-olds and respiratory infections: an RCT. Pediatrics. 2014 Jun;133(6):e1533-40. doi: 10.1542/peds.2013-3598. Epub 2014 May 19.

Reference Type DERIVED
PMID: 24843061 (View on PubMed)

Other Identifiers

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6012

Identifier Type: -

Identifier Source: org_study_id