Efficacy of Plant Sterol-Fortified Dairy Product on Plasma Lipid and Plant Sterol Concentrations in Humans

NCT ID: NCT01478789

Last Updated: 2011-12-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

47 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-09-30

Study Completion Date

2011-10-31

Brief Summary

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The aim of this clinical study was to determine the efficacy on plasma cholesterol-lowering of a water dispersible formulation of plant sterol (WD-PS) preparation versus plant sterol esters (PS-ester), consumed within dairy products.

Detailed Description

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Forty-seven hyperlipidemic subjects (25 males and 22 females, age 19-75 years at baseline) completed the double-blind, randomized, crossover study.

Conditions

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Hypercholesterolemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Water dispersible Plant Sterol (WD-PS)

WD-PS dairy product (a novel formulation for dispersible free sterols in aqueous media produced)2g/d of free plant sterol

Group Type EXPERIMENTAL

WD-PS intervention phase

Intervention Type DIETARY_SUPPLEMENT

2g/d of free plant sterol in 100g yogurt

Esterified plant sterol (PS-Ester)

PS-Ester enriched dairy product (2g/d free plant sterol)

Group Type EXPERIMENTAL

PS-Ester intervention phase

Intervention Type DIETARY_SUPPLEMENT

2g/d of free plant sterol in 100g yogurt

placebo

100 g/d yogurt with no added plant sterol

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DIETARY_SUPPLEMENT

100g/d yogurt with no added plant sterol

Interventions

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WD-PS intervention phase

2g/d of free plant sterol in 100g yogurt

Intervention Type DIETARY_SUPPLEMENT

PS-Ester intervention phase

2g/d of free plant sterol in 100g yogurt

Intervention Type DIETARY_SUPPLEMENT

placebo

100g/d yogurt with no added plant sterol

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* healthy individuals aged 19-60 yr
* plasma LDL-C levels \> 3.0mmol/l
* TG \< 4.5mmol/l
* body mass index (BMI) between 20 and 30 kg/m2.

Exclusion Criteria

* history of recent or chronic use of oral hypolipidemic therapy, including fish oils, or probucol within the last 3 months
* history of chronic use of alcohol (\>2 drinks/d)
* smoking
* myocardial infarction, coronary artery bypass, sitosterolaemia, kidney disease, liver disease or other major surgical procedures within the last six months
Minimum Eligible Age

19 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Manitoba

OTHER

Sponsor Role lead

Responsible Party

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Dr. Peter Jones

Director of the Richardson Centre for Functional Foods and Nutraceuticals

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Richarson Centre for Funtional Foods and Nutraceuticals

Winnipeg, Manitoba, Canada

Site Status

Countries

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Canada

Other Identifiers

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B2010:096

Identifier Type: -

Identifier Source: org_study_id