An Evaluation of Polymer Based Fiducials for Use in Imaging Patients Receiving Treatment for Prostate Cancer

NCT ID: NCT01478412

Last Updated: 2011-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-12-31

Brief Summary

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This trial is to determine if prostate target delineation obtained through an ultrasound based system is equivalent in accuracy to the MRI image fusion, and if alignment correction vectors obtained from ultrasound imaging are of equivalent accuracy to orthogonal X-ray imaging for daily prostate positioning.

Detailed Description

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The investigators will also be assessing the following:

1. Whether polymer-based markers can be adequately visualized on daily stereoscopic imaging compared to gold seed markers.
2. Whether polymer-based markers are visible on ultrasound imaging.
3. To determine if the polymer-based marker produces fewer artifacts on treatment planning CT scans than gold markers.

Conditions

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Prostate Adenocarcinoma

Keywords

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Prostate cancer Low risk Intermediate risk T1 T2a T2b Gleason 6 Gleason 7 PSA 10 PSA 20

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Males with prostate adenocarcinoma

English speaking males with histologically confirmed prostate adenocarcinoma and diagnosis of low risk or intermediate risk prostate cancer.

Polymer based fiducial placement

Intervention Type OTHER

Fiducial marker placement with rectal ultrasound imaging.

Interventions

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Polymer based fiducial placement

Fiducial marker placement with rectal ultrasound imaging.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Histologically confirmed prostate adenocarcinoma
* diagnosis of low risk or intermediate risk prostate cancer
* approved for proton therapy treatment at CDH ProCure Proton Therapy Center
* prescribed and consented for the placement of fiducial markers into the prostate as part of the standard treatment procedure
* capable of receiving an MRI of the pelvis region for prostate localization
* the prostate gland of eligible patients must be capable of imaging from an anterior trans-abdominal ultrasound as determined by the treating investigator
* must be fluent in the English language; must be able to provide written study consent

Exclusion Criteria

* Evidence of a large TURP defect per investigator discretion
* previous prostate cancer surgery including prostatectomy, hyperthermia and cryosurgery
* previous pelvic radiation for prostate cancer
* current grade 2 or above incontinence
* history of orthopedic procedures in the area of the treatment, specifically no prior hip replacement or procedure in which metallic or high density material remains which would be within stereoscopic kilovoltage imaging area
* prior permanent placement of any metallic or high density material within the prostate
* known allergy to ultrasonic gel
Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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John Chang, MD

OTHER

Sponsor Role lead

Responsible Party

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John Chang, MD

John Chang, MD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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John Chang, MD

Role: PRINCIPAL_INVESTIGATOR

ProCure Proton Therapy Center

Locations

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ProCure Proton Therapy Center

Warrenville, Illinois, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Lori A Abruscato, BS

Role: CONTACT

Phone: 630-821-6397

Email: [email protected]

Facility Contacts

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Lori A Abruscato, BS

Role: primary

Related Links

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Other Identifiers

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CHI-001

Identifier Type: -

Identifier Source: org_study_id