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Cognitive Correlates of Antidepressant Treatment Response in Elders

NCT ID: NCT01477268

Last Updated: 2011-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-06-30

Study Completion Date

2009-10-31

Brief Summary

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Major depression is a very common health problem affecting older persons. The present standard of treatment is with medications called "antidepressants". Antidepressants have been studied extensively in older persons with normal brain function and have been shown to be effective. However, certain types of brain dysfunction called "executive impairment" (inability to do higher order thinking) may lead to poor treatment outcomes. This study will compare how older depressed people with different levels of executive impairment respond differently to standard antidepressant treatment. Knowing this information will lead to more rational targeting of available treatments, leading to improved treatment outcomes.

Detailed Description

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Conditions

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Depression

Keywords

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antidepressants depression zoloft psychiatry psychology

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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zoloft

Both arms of the study will include zoloft. However, the treatment response to zoloft will be compared in two different subgroups.

Group Type OTHER

Zoloft (antidepressant)

Intervention Type DRUG

Zoloft 50-200 mg po od x 12 weeks

Interventions

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Zoloft (antidepressant)

Zoloft 50-200 mg po od x 12 weeks

Intervention Type DRUG

Other Intervention Names

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Sertraline

Eligibility Criteria

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Inclusion Criteria

* above the age of 65,
* speak English fluently,
* experience depression, AND
* not yet on active treatment.

Exclusion Criteria

* active delirium,
* substance abuse,
* mental illness other than major depression,
* active CNS disease,
* unstable systematic medical disease, OR
* current of past psychotic disorder.
Minimum Eligible Age

65 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Unity Health Toronto

OTHER

Sponsor Role lead

Responsible Party

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St. Michael's Hospital

Principal Investigators

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Corinne Fischer, MD

Role: PRINCIPAL_INVESTIGATOR

St. Michaels Hospital

Locations

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St Michael's Hospital

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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06-296

Identifier Type: -

Identifier Source: org_study_id