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Determination of Glycemic and Insulinemic Indices

NCT ID: NCT01477216

Last Updated: 2011-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

142 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-01-31

Study Completion Date

2013-12-31

Brief Summary

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The aim of this study to investigate methodological aspects that may affect glycemic index (GI) and insulinemic (II) values. In addition, we will measure GI and II values for typical Finnish carbohydrate-rich foods and provide a database of GIs for Finnish foods.

The specific aims of this study are:

* to compare glycemic responses and GIs analyzed from capillary and venous blood to compare glucose against white bread as the reference food, and to study the effect of number of reference tests on GI values. For each setting of the tested parameters, we determined the glycemic indices of rye bread, oatmeal porridge and instant mashed potato
* to examine the glycaemic and insulinaemic responses of a mashed potato-based meal when a high fat food (rapeseed oil) or a high protein food (chicken breast) or fat, protein and salad together were added to the meal. Furthermore, we studied how the predicted and measured GI values of the mixed meal differed from each other.
* to examine the effects of two different coffee portions with glucose and caffeine-containing soft drinks on postprandial glucose and insulin responses. Further objectives were to study how coffee and different accompaniments affect glucose and insulin responses.
* to measure GI values for typical Finnish foods
* to study the effects of berries on glycemic and insulinemic responses
* to examine the effects of overweight and glucose tolerance on the glucose, insulin and lipid responses to an HGI meal and an LGI meal.Furthermore, the second aim was to study the effect of BMI and glucose tolerance on the GI measured.
* to compare methodological choices in insulin measurement
* to investigate the effect of alcohol on postprandial glucose and insulin responses, and to determine glycemic and insulinemic indices values for beer and non-alcoholic beer

Detailed Description

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Conditions

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Glucose Metabolism

Keywords

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Glycemic index Glycemic responses Insulin responses Insulinemic index Carbohydrates Methodology Glucose metabolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Measuring method

To compare glycemic responses and GI values from capillary and venous blood and to compare glucose solution with white bread as the reference food and to study the effect of the number of reference tests on GI values.

Group Type EXPERIMENTAL

ELSA 1-9

Intervention Type OTHER

Measuring GI and II values for Finnish foods

Mixed meals

To examine the glycaemic and insulinaemic responses of a mashed potato-based meal when a high fat food (rapeseed oil) or a high protein food (chicken breast) or fat, protein and salad together were added to the meal. Furthermore, we studied how the predicted and measured GI values of the mixed meal differed from each other.

Group Type EXPERIMENTAL

ELSA 1-9

Intervention Type OTHER

Measuring GI and II values for Finnish foods

Coffee

To examine the effects of two different coffee portions with glucose and caffeine-containing soft drinks on postprandial glucose and insulin responses. Further objectives were to study how coffee and different accompaniments affect glucose and insulin responses.

Group Type EXPERIMENTAL

ELSA 1-9

Intervention Type OTHER

Measuring GI and II values for Finnish foods

Snacks

To measure GI and II values for Finnish snack foods

Group Type EXPERIMENTAL

ELSA 1-9

Intervention Type OTHER

Measuring GI and II values for Finnish foods

Berries

To study the effects of berries on glycemic and insulinemic responses

Group Type EXPERIMENTAL

ELSA 1-9

Intervention Type OTHER

Measuring GI and II values for Finnish foods

GIs of low-carbs

To measure glycemic and insulinemic responses to low-carbohydrates foods

Group Type EXPERIMENTAL

ELSA 1-9

Intervention Type OTHER

Measuring GI and II values for Finnish foods

Glucose metabolism and BMI

To examine the effects of overweight and glucose tolerance on the glucose, insulin and lipid responses to an HGI meal and an LGI meal. Furthermore, the second aim was to study the effect of BMI and glucose tolerance on the GI measured.

Group Type EXPERIMENTAL

ELSA 1-9

Intervention Type OTHER

Measuring GI and II values for Finnish foods

Insulin measurement

To compare how methodological choices affect measured insulin values

Group Type EXPERIMENTAL

ELSA 1-9

Intervention Type OTHER

Measuring GI and II values for Finnish foods

Alcohol

To investigate the effect of alcohol on postprandial glucose and insulin responses, and to determine glycemic and insulinemic indices values for beer and non-alcoholic beer.

Group Type EXPERIMENTAL

ELSA 1-9

Intervention Type OTHER

Measuring GI and II values for Finnish foods

Interventions

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ELSA 1-9

Measuring GI and II values for Finnish foods

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* For Studies 1-9 a total of 12 to 24 volunteers per study with a normal glucose tolerance based upon a 2 h 75g oral glucose tolerance test (OGTT).
* For Study 7 a total of 24 volunteers with impaired glucose tolerance based on an OGTT.
* For Studies 1-6 and 8-9 with an age of 20 to 60 and with a BMI of 18 to 30 kg/m2.
* For Study 7 an age of 62 to 72 and with a BMI of 20 to 35 kg/m2.

Exclusion Criteria

* First-degree family history of diabetes
* An active gastrointestinal or metabolic disease
* For Studies 1-6 and 8-9 chronic medication (oral contraceptives were allowed)
* For Study 7 regular medication that would have affect glucose and lipid metabolism
* Smoking
* Pregnancy
* Breastfeeding
* History of polycystic ovary syndrome
* History of gestational diabetes
Minimum Eligible Age

20 Years

Maximum Eligible Age

72 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Finnish Institute for Health and Welfare

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Liisa M Valsta, DSc

Role: STUDY_DIRECTOR

National Institute for Health and Welfare, Helsinki, Finland

Katja A Hätönen

Role: PRINCIPAL_INVESTIGATOR

National Institute for Health and Welfare, Helsinki, Finland

References

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Hatonen KA, Virtamo J, Eriksson JG, Perala MM, Sinkko HK, Leiviska J, Valsta LM. Modifying effects of alcohol on the postprandial glucose and insulin responses in healthy subjects. Am J Clin Nutr. 2012 Jul;96(1):44-9. doi: 10.3945/ajcn.111.031682. Epub 2012 May 30.

Reference Type DERIVED
PMID: 22648716 (View on PubMed)

Other Identifiers

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TUSU 182-5

Identifier Type: -

Identifier Source: org_study_id