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Cerebral Blood Circulation in Patients With Posterior Fossa Brain Tumor

NCT ID: NCT01476670

Last Updated: 2011-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-07-31

Brief Summary

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The normal cerebral blood flow is guided by factors such as cerebral autoregulation (CA) and carbon dioxide reactivity (CO2R). Authors have demonstrated that CA and CO2R may be impaired in presence of intracranial tumors.Most studies pertaining to assessment of CA and CO2R in patients with brain tumors is limited to supratentorial tumors. Due to their anatomic location, posterior fossa tumors result in obstruction of ventricular outflow, produce hydrocephalus and features of raise intracranial pressure (ICP). It is possible that lesions in the posterior fossa may affect CA and CO2R. It should also be noted that posterior fossa surgeries are carried out in positions such as prone, lateral and sitting. Altered surgical positions themselves affect systemic hemodynamics which may influence cerebral blood flow; with presence of anesthetics further compromising the blood flow to the brain. Understanding the homeostatic mechanisms of CA and CO2R may help in deciding proper positioning of patients and maintenance of intraoperative hemodynamic.

The aim of this observational study was to evaluate CA and CO2R in patients with posterior fossa tumor prior to surgical decompression of the lesion.

Detailed Description

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Conditions

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Brain Tumor

Keywords

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Posterior fossa brain tumor Cerebral blood flow Cerebral autoregulation Carbon dioxide reactivity Transcranial Doppler

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Posterior fossa tumor

Patients with posterior fossa tumor scheduled for elective surgery will be enrolled in the study.

Monitoring

Intervention Type OTHER

Transcranial Doppler will be used to assess the cerebral autoregulation and carbon dioxide reactivity of patients with posterior fossa tumor

Interventions

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Monitoring

Transcranial Doppler will be used to assess the cerebral autoregulation and carbon dioxide reactivity of patients with posterior fossa tumor

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All patients with posterior fossa tumor
* Scheduled for elective surgery
* History of recent ventriculoperitoneal shunt (within 24 hours)

Exclusion Criteria

* previous craniotomy
* patients on ventilatory support
* history of cerebrovascular accident
* syncope or carotid artery disease
* anemia
* polycythemia
* patients on vasoactive medications
* those suffering from medical conditions such as diabetes mellitus and hypertension.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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All India Institute of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Hemanshu Prabhakar

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hemanshu Prabhakar, MD

Role: PRINCIPAL_INVESTIGATOR

All India Institute of Medical Sciences

Locations

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All India Institute of Medical Sciences

New Delhi, National Capital Territory of Delhi, India

Site Status

Countries

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India

Central Contacts

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Hemanshu Prabhakat, MD

Role: CONTACT

Phone: 9868398205

Email: [email protected]

Facility Contacts

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Hemanshu Prabhakar, MD

Role: primary

Other Identifiers

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Posterior fossa tumor - TCD

Identifier Type: OTHER

Identifier Source: secondary_id

CA-CO2-TCD

Identifier Type: -

Identifier Source: org_study_id