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Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer

NCT ID: NCT01470586

Last Updated: 2011-11-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-05-31

Study Completion Date

2011-06-30

Brief Summary

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Study of Oxidative stress Markers (F2 Isoprostanes for lipid peroxidation, Carbonyl groups for protein peroxidation, 3 Nitrotyrosine for damage by nitrogens, and 8-Hydroxyguanosine for RNA peroxidation)in patients with colorectal cancer undergo surgical treatment (preoperatively during the intervention and postoperatively) and controls.

Detailed Description

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Study of the impact of surgery on Lipid peroxidation, Protein peroxidation, damage by nitrogens, and RNA peroxidation, in patients undergo surgical resection for colorectal cancer and compared with controls, and validation of the responsiveness of oxidative stress markers on surgery

Conditions

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Colorectal Cancer Colon Rectal Resection Oxidative Stress

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Surgery for colorectal cancer

Colorectal cancer patients

Group Type OTHER

Surgery for colorectal cancer

Intervention Type PROCEDURE

Surgical resection of colorectal cancer

Controls

Controls

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Surgery for colorectal cancer

Surgical resection of colorectal cancer

Intervention Type PROCEDURE

Other Intervention Names

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Open or Laparoscopic resection for colorectal cancer Low anterior resection Sigmoidectomy Left colectomy Trasverse colectomy Right colectomy

Eligibility Criteria

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Inclusion Criteria

* Patients with colorectal cancer
* Controls

Exclusion Criteria

* ASA\>3
* Metastatic Disease
* Acute bowel obstruction
* Acute bowel perforation
* BMI\<30
* Chronic Systemic or Autoimmune Diseases
* Smokers
* Alcohol consumers
Minimum Eligible Age

25 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Ioannina

OTHER

Sponsor Role collaborator

G. Hatzikosta General Hospital

OTHER

Sponsor Role lead

Responsible Party

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E.Tsimoyiannis

Head of Department of Surgery, G.Hatzikosta General Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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George Pappas-Gogos, MD

Role: PRINCIPAL_INVESTIGATOR

G. Hatzikosta General Hospital

Locations

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G. Hatzikosta General Hospital

Ioannina, Epirus, Greece

Site Status

Countries

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Greece

Other Identifiers

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GH-1948-08

Identifier Type: -

Identifier Source: org_study_id