Open-Label Pilot Study of Guanfacine-Extended Release for the Treatment of Cannabis Dependence

NCT ID: NCT01467999

Last Updated: 2019-02-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 22 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-02-29
• Study Completion Date: 2016-10-31

Brief Summary

The purpose of this study is to determine whether guanfacine represents a tolerable, potentially effective pharmacotherapy option for cannabis dependence. Interested in seeing whether guanfacine treatment reduces marijuana consumption, withdrawal symptoms, and craving as compared to baseline.

Detailed Description

Cannabis use disorders remain the most common illicit drug use disorder and options for treatment remain limited. Compared to other abusable substances, there has been little investigation of pharmacotherapies for cannabis dependence and no effective pharmacotherapy for cannabis dependence has been developed yet. As such, the development of effective cannabis dependence pharmacotherapy is an important unmet public health need. Lofexidine, an alpha-2 agonist, is effective in treating opioid withdrawal and shows promise as cannabis use disorder pharmacotherapy, though its use may be limited by a cumbersome (thrice daily) dosing regimen. An alpha-2-agonist with a longer half-life, such as guanfacine, may have some of the same benefits as lofexidine at comparable doses, but its easier (once daily) dosing regimen may promote compliance and treatment retention. The purpose of this study is therefore to determine whether guanfacine represents a tolerable, potentially effective pharmacotherapy option for cannabis dependence. This pilot study can also provide the basis for subsequently conducting a larger study aimed at determining efficacy with the appropriate randomized, placebo-controlled design.

Conditions

Cannabis Dependence

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Guanfacine

Guanfacine, 4mg given once daily

Group Type: EXPERIMENTAL

Guanfacine

Intervention Type: DRUG

Guanfacine, 4mg given once daily

Interventions

Guanfacine

Guanfacine, 4mg given once daily

Intervention Type: DRUG

Other Intervention Names

Intuniv

Eligibility Criteria

Inclusion Criteria

• Men and women between the ages of 18-60 who meet DSM-IV criteria for current marijuana dependence
• Individuals must report using marijuana at least 20 days in the past 30 days and have a positive urine test for THC on the day of study entry.
• Individual must describe marijuana as their primary drug of abuse.
• Individuals must be capable of giving informed consent and capable of complying with study procedures.

Exclusion Criteria

• Meets DSM-IV-TR criteria for schizophrenia, schizoaffective illness, psychotic disorder other than transient psychosis due to drug abuse, major depression, bipolar illness or psychiatric disorders (other than substance abuse) which require psychiatric intervention.
• Unstable medication conditions, such as poorly controlled diabetes or hypertension (>140/90 mmHg), which might make participation hazardous.
• Individuals with liver enzyme function tests greater than three times normal, or acute hepatitis
• Individuals with a history of a seizure disorder
• Individuals with current suicidal risk.
• Individuals who are cognitively impaired
• Bradycardia (< 50 beats/minute), hypotension (sitting or standing BP < 90/50), or symptoms attributable to low BP (i.e. lightheadedness or dizziness on standing).
• Nursing mothers and pregnant women. Women of child bearing age will be included in the study provided that they are not pregnant, based on the results of a blood pregnancy test drawn at the time of screening. They must also agree to use a method of contraception with proven efficacy and agree not to become pregnant during the study. To confirm this, urine pregnancy tests will be repeated monthly. Women will be provided a full explanation of the potential dangers of pregnancy while on the study medication. If a woman becomes pregnant, the study medication will be discontinued.
• Individuals who are physiologically dependent on any other drugs (excluding nicotine) that would require a medical intervention
• Individuals with known sensitivity to alpha-2 Agonists
• Individuals with coronary vascular disease as indicated by history or suspected by abnormal ECG or history of cardiac symptoms
• Individuals currently being treated with antihypertensive medication, including alpha-2 agonists
• Individuals currently taking medications that may interact adversely with guanfacine.
• Individuals who are court-mandated to treatment.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

New York State Psychiatric Institute

OTHER

Sponsor Role: lead

Responsible Party

Frances R Levin

Director of Substance Use Disorder

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Frances Levin, M.D.

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Elias Dakwar, M.D.

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

STARS

New York, New York, United States

Countries

United States

Other Identifiers

6393

Identifier Type: OTHER

Identifier Source: secondary_id

#6393

Identifier Type: -

Identifier Source: org_study_id