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Metacarpophalangeal Joint Reconstruction Using a Vascularized Cartilage and Bone Graft

NCT ID: NCT01467752

Last Updated: 2011-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-01-31

Study Completion Date

2009-12-31

Brief Summary

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Traumatic cartilage loss of the joint is central to the development of joint failure in arthritis. The study on the use of a bone graft for reconstruction of metacarpophalangeal joint defects.

Detailed Description

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The metacarpophalangeal joint is vital for hand function. Cartilage loss of the joint is central to the development of joint failure in arthritis. Although various treatments have been proposed, the management remains a challenging problem.Previous anatomical studies have shown that, at the base of the metacarpal, there were nutrient arteries inserting into the dorsum of the metacarpal. The nutrient arteries arise from the distal and middle dorsal carpal arches that run distally to the first to fourth dorsal metacarpal arteries (DMAs. These studies prompt us to use a reverse vascularized cartilage and bone graft based on the DMA. The metacarpal consists of a widened proximal base. The joint surface to the capitate is convex anteriorly and dorsally concave, where it extends to the styloid process on the dorsolateral aspect of the metacarpal base. The unique contour stimulates our imagination and creativity to use a portion of the joint surface for reconstruction of metacarpophalangeal joint defects. The purpose of this study is to report the novel technique and to evaluate the effectiveness of the treatment.

Conditions

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Volar Plate Injury, Thumb, Metacarpophalangeal Joint

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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MCP joint

reconstruction of metacarpophalangeal (MCP) joint

Group Type EXPERIMENTAL

MCP joint

Intervention Type PROCEDURE

reconstruction of metacarpophalangeal (MCP) joint using a bone graft

Interventions

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MCP joint

reconstruction of metacarpophalangeal (MCP) joint using a bone graft

Intervention Type PROCEDURE

Other Intervention Names

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MCP joint reconstruction

Eligibility Criteria

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Inclusion Criteria

1. a cartilage defect at either proximal or distal MCP joint;
2. either an acute or old injury;
3. loss of 1/4 of joint entire surface that seen on plain radiographs, CT scan, and intraoperative finding;
4. and with or without MCP joint subluxation.

Exclusion Criteria

1. large defects involved double joint surfaces;
2. the size of the defect involving less than 1/4 of the joint surface;
3. associate with infection or other diseases that restrict to use the technique.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Second Hospital of Qinhuangdao

OTHER

Sponsor Role lead

Responsible Party

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Xu Zhang

Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xu Zhang, MD

Role: STUDY_CHAIR

The Second Hospital of Qinhuangdao

Locations

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The second hospital of Qinhuangdao

Qinhuangdao, Hebei, China

Site Status

Countries

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China

References

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Sebastin SJ, Mendoza RT, Chong AKS, Peng YP, Ono S, Chung KC, Lim AYT. Application of the dorsal metacarpal artery perforator flap for resurfacing soft-tissue defects proximal to the fingertip. Plast Reconstr Surg. 2011 Sep;128(3):166e-178e. doi: 10.1097/PRS.0b013e318221ddfa.

Reference Type RESULT
PMID: 21865990 (View on PubMed)

Related Links

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http://www.ncbi.nlm.nih.gov/pubmed?term=Application%20of%20the%20dorsal%20metacarpal%20artery%20perforator%20flap%20for%20resurfacing%20soft-tissue%20defects%20proximal%20to%20the%20fingertip.

Application of the dorsal metacarpal artery perforator flap for resurfacing soft-tissue defects proximal to the fingertip

Other Identifiers

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SHQ

Identifier Type: OTHER

Identifier Source: secondary_id

XZhang201111

Identifier Type: -

Identifier Source: org_study_id