Trial Outcomes & Findings for Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section (NCT NCT01465191)
NCT ID: NCT01465191
Last Updated: 2020-12-10
Results Overview
IV morphine use in milligrams, by participant-controlled analgesia will be assessed every 6 hours for 24 hours postoperatively.
Recruitment status
COMPLETED
Study phase
PHASE4
Target enrollment
169 participants
Primary outcome timeframe
24 hours
Results posted on
2020-12-10
Participant Flow
Participant milestones
| Measure |
50 Micrograms Spinal Morphine
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
After interim analysis, the genetics part of the analysis was dropped and the study completed.
|
100 mcg Spinal Morphine
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
After interim analysis, the genetics part of the analysis was dropped and the study completed.
|
150 mcg Spinal Morphine
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
After interim analysis, the genetics part of the analysis was dropped and the study completed.
|
|---|---|---|---|
|
Overall Study
STARTED
|
56
|
63
|
50
|
|
Overall Study
COMPLETED
|
47
|
54
|
43
|
|
Overall Study
NOT COMPLETED
|
9
|
9
|
7
|
Reasons for withdrawal
| Measure |
50 Micrograms Spinal Morphine
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
After interim analysis, the genetics part of the analysis was dropped and the study completed.
|
100 mcg Spinal Morphine
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
After interim analysis, the genetics part of the analysis was dropped and the study completed.
|
150 mcg Spinal Morphine
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
After interim analysis, the genetics part of the analysis was dropped and the study completed.
|
|---|---|---|---|
|
Overall Study
Protocol Violation
|
6
|
3
|
3
|
|
Overall Study
Lost to Follow-up
|
3
|
6
|
4
|
Baseline Characteristics
Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section
Baseline characteristics by cohort
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
these subjects will receive 50 mcg spinal morphine
|
100 Micrograms Spinal Morphine
n=54 Participants
these subjects will receive 100 mcg spinal morphine
|
150 Micrograms Spinal Morphine
n=43 Participants
these subjects will receive 150 mcg spinal morphine
|
Total
n=144 Participants
Total of all reporting groups
|
|---|---|---|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
47 Participants
n=5 Participants
|
54 Participants
n=7 Participants
|
43 Participants
n=5 Participants
|
144 Participants
n=4 Participants
|
|
Age, Categorical
>=65 years
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Age, Continuous
|
33 years
STANDARD_DEVIATION 6 • n=5 Participants
|
33 years
STANDARD_DEVIATION 5 • n=7 Participants
|
33 years
STANDARD_DEVIATION 6 • n=5 Participants
|
33 years
STANDARD_DEVIATION 4 • n=4 Participants
|
|
Sex: Female, Male
Female
|
47 Participants
n=5 Participants
|
54 Participants
n=7 Participants
|
43 Participants
n=5 Participants
|
144 Participants
n=4 Participants
|
|
Sex: Female, Male
Male
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Region of Enrollment
United States
|
47 participants
n=5 Participants
|
54 participants
n=7 Participants
|
43 participants
n=5 Participants
|
144 participants
n=4 Participants
|
PRIMARY outcome
Timeframe: 24 hoursIV morphine use in milligrams, by participant-controlled analgesia will be assessed every 6 hours for 24 hours postoperatively.
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Milligrams of Intravenous Morphine Used by Participant in First 24 Hours Postoperatively
|
18 Milligrams
Interval 8.0 to 29.0
|
14 Milligrams
Interval 6.0 to 27.0
|
15 Milligrams
Interval 5.0 to 23.0
|
SECONDARY outcome
Timeframe: 6 hours post-operativelyVisual analog pain scale measures pain on a 100 millimeter (mm) scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst pain imaginable" (100mm). Pain measured at rest and with movement.
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale (VAS) Pain at 6 Hours
Rest
|
20 mm
Interval 10.0 to 39.0
|
25 mm
Interval 8.0 to 43.0
|
15 mm
Interval 2.0 to 35.0
|
|
Visual Analog Scale (VAS) Pain at 6 Hours
Movement
|
43 mm
Interval 27.0 to 62.0
|
43 mm
Interval 28.0 to 65.0
|
30 mm
Interval 13.0 to 52.0
|
SECONDARY outcome
Timeframe: 12 hours post-operativelyVisual analog pain scale measures pain on a 100 millimeter (mm) scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst pain imaginable" (100mm). Pain measured at rest and with movement.
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale (VAS) Pain at 12 Hours
Rest
|
20 mm
Interval 0.0 to 35.0
|
15 mm
Interval 0.0 to 36.0
|
10 mm
Interval 3.0 to 22.0
|
|
Visual Analog Scale (VAS) Pain at 12 Hours
Movement
|
30 mm
Interval 10.0 to 60.0
|
35 mm
Interval 17.0 to 63.0
|
30 mm
Interval 11.0 to 62.0
|
SECONDARY outcome
Timeframe: 18 hours post-operativelyVisual analog pain scale measures pain on a 100 millimeter (mm) scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst pain imaginable" (100mm). Pain measured at rest and with movement.
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale (VAS) Pain at 18 Hours
Rest
|
17 mm
Interval 0.0 to 35.0
|
11 mm
Interval 0.0 to 28.0
|
5 mm
Interval 0.0 to 19.0
|
|
Visual Analog Scale (VAS) Pain at 18 Hours
Movement
|
32 mm
Interval 10.0 to 50.0
|
30 mm
Interval 0.0 to 40.0
|
26 mm
Interval 0.0 to 40.0
|
SECONDARY outcome
Timeframe: 24 hours post-operativelyVisual analog pain scale measures pain on a 100 millimeter (mm) scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst pain imaginable" (100mm). Pain measured at rest and with movement.
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale (VAS) Pain at 24 Hours
Rest
|
24 mm
Interval 9.0 to 43.0
|
21 mm
Interval 6.0 to 50.0
|
18 mm
Interval 0.0 to 32.0
|
|
Visual Analog Scale (VAS) Pain at 24 Hours
Movement
|
43 mm
Interval 22.0 to 65.0
|
41 mm
Interval 21.0 to 68.0
|
41 mm
Interval 21.0 to 68.0
|
SECONDARY outcome
Timeframe: 6 hours post-operativelyVisual analog nausea/vomiting scale measures nausea and vomiting on a 100mm scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst Nausea/Vomiting Imaginable" (100mm).
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale- Nausea/Vomiting at 6 Hours
|
0 mm
Interval 0.0 to 15.0
|
7 mm
Interval 0.0 to 40.0
|
0 mm
Interval 0.0 to 40.0
|
SECONDARY outcome
Timeframe: 12 hours post-operativelyVisual analog nausea/vomiting scale measures nausea and vomiting on a 100mm scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst Nausea/Vomiting Imaginable" (100mm).
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale- Nausea/Vomiting at 12 Hours
|
0 mm
Interval 0.0 to 5.0
|
0 mm
Interval 0.0 to 6.0
|
0 mm
Interval 0.0 to 10.0
|
SECONDARY outcome
Timeframe: 18 hours post-operativelyVisual analog nausea/vomiting scale measures nausea and vomiting on a 100mm scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst Nausea/Vomiting Imaginable" (100mm).
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale- Nausea/Vomiting at 18 Hours
|
0 mm
Interval 0.0 to 2.0
|
0 mm
Interval 0.0 to 0.0
|
0 mm
Interval 0.0 to 0.0
|
SECONDARY outcome
Timeframe: 24 hours post-operativelyVisual analog nausea/vomiting scale measures nausea and vomiting on a 100mm scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst Nausea/Vomiting Imaginable" (100mm).
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale- Nausea/Vomiting at 24 Hours
|
0 mm
Interval 0.0 to 4.0
|
0 mm
Interval 0.0 to 2.0
|
0 mm
Interval 0.0 to 0.0
|
SECONDARY outcome
Timeframe: 6 hours post-operativelyVisual analog pruritus scale measures itching on a 100mm scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst Itching Imaginable" (100mm).
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale Pruritus (Itching) at 6 Hours
|
21 mm
Interval 10.0 to 45.0
|
37 mm
Interval 3.0 to 73.0
|
39 mm
Interval 19.0 to 65.0
|
SECONDARY outcome
Timeframe: 12 hours post-operativelyVisual analog pruritus scale measures itching on a 100mm scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst Itching Imaginable" (100mm).
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale Pruritus (Itching) at 12 Hours
|
10 mm
Interval 0.0 to 20.0
|
23 mm
Interval 0.0 to 64.0
|
25 mm
Interval 0.0 to 45.0
|
SECONDARY outcome
Timeframe: 18 hours post-operativelyVisual analog pruritus scale measures itching on a 100mm scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst Itching Imaginable" (100mm).
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale Pruritus (Itching) at 18 Hours
|
9 mm
Interval 0.0 to 20.0
|
13 mm
Interval 0.0 to 47.0
|
5 mm
Interval 0.0 to 25.0
|
SECONDARY outcome
Timeframe: 24 hours post-operativelyVisual analog pruritus scale measures itching on a 100mm scale. Participants make a mark on the scale with one end labeled "None" (0mm) and the other labeled "Worst Itching Imaginable" (100mm).
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Scale Pruritus (Itching) at 24 Hours
|
7 mm
Interval 0.0 to 16.0
|
12 mm
Interval 0.0 to 39.0
|
6 mm
Interval 0.0 to 30.0
|
SECONDARY outcome
Timeframe: 24 hours postoperativelyVisual analog patient satisfaction scale measures satisfaction with analgesia on a 100mm scale. Participants make a mark on the scale with one end labeled "Completely Dissatisfied" (0mm) and the other labeled "Completely Satisfied" (100mm).
Outcome measures
| Measure |
50 Micrograms Spinal Morphine
n=47 Participants
Subjects will receive 50 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
100 Micrograms Spinal Morphine
n=54 Participants
Subjects will receive 100 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
150 Micrograms Spinal Morphine
n=43 Participants
Subjects will receive 150 mcg morphine in their spinal anesthetic for cesarean section
Morphine: Morphine will be given via spinal injection at doses of 50, 100, 150 micrograms as part of a spinal anesthetic for cesarean section
|
|---|---|---|---|
|
Visual Analog Patient Satisfaction With Analgesia at 24 Hours
|
85 mm
Interval 65.0 to 100.0
|
83 mm
Interval 67.0 to 100.0
|
84 mm
Interval 70.0 to 100.0
|
Adverse Events
50 Micrograms Spinal Morphine
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
100 Micrograms Spinal Morphine
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
150 Micrograms Spinal Morphine
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place