Cortisone Treatment for the Prevention of Postoperative Pancreatitis and Pancreatitis-induced Complications After Pancreaticoduodenectomy and Distal Pancreatic Resection

NCT ID: NCT01460615

Last Updated: 2018-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Study Classification

INTERVENTIONAL

Study Start Date

2011-02-28

Study Completion Date

2017-01-31

Brief Summary

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The purpose of this randomized, placebo-controlled trial is to investigate whether postoperative pancreatitis and other immediate complications after pancreaticoduodenectomy or distal pancreatic resection may be reduced with cortisone treatment. Treatment is administered to high risk patients (defined by high amount of acinar cells in the cut edge of pancreas).

Detailed Description

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Conditions

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Postoperative Complications Postoperative Pancreatitis

Interventions

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Hydrocortisone

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Pancreaticoduodenectomy and distal pancreatectomy patients in Tampere University Hospital

Exclusion Criteria

* Patients with an ongoing cortisone treatment
* Cefuroxime allergy
* Chronic pancreatitis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tampere University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Tampere University Hospital

Tampere, , Finland

Site Status

Countries

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Finland

References

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Laaninen M, Sand J, Nordback I, Vasama K, Laukkarinen J. Perioperative Hydrocortisone Reduces Major Complications After Pancreaticoduodenectomy: A Randomized Controlled Trial. Ann Surg. 2016 Nov;264(5):696-702. doi: 10.1097/SLA.0000000000001883.

Reference Type DERIVED
PMID: 27429037 (View on PubMed)

Other Identifiers

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R11009M

Identifier Type: -

Identifier Source: org_study_id

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