The Effectiveness of Oral Corticosteroids in the Treatment of Lumbar Stenosis

NCT ID: NCT01456377

Last Updated: 2011-10-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2012-06-30

Brief Summary

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The aim of this study is to evaluate the effectiveness of the use of systemic corticosteroids administered orally in narrow lumbar canal syndrome.

Detailed Description

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60 patients are being randomized, plank by randomization, the patient and the examiner will be blinded. Will be placed in opaque brown envelopes in order to maintain the secrecy of allocation.

Included patients aged between 50 and 75 years of both sexes participate in the work to accept and sign the Informed Consent The patient will be screened in advance after the acceptance of it will be an anthropometric assessment, with assessment of height, weight and presence of associated comorbidities.

After clinical evaluation they headed for the initial evaluation, after this evaluation, patients are randomized and and delivered to the patient the medication with corticosteroids or placebo for an unrelated medical research. It is also given a bottle of paracetamol 750 mg and a sheet dated, in which the patient is instructed to register the day this sheet and number of capsules taken, which is also an evaluation factor.

evaluation VAS SF 36 Roland Morris questionnaire Test 6-minute walk Likert scale ELegibility Criteria

Clinical diagnosis:

Low back pain and at least two of the following complaints in lower limbs: pain, weakness, burning or numbness that worsens with walking and improves with the cessation of walking.

Radiological diagnosis:

Presence of lumbar canal stenosis with an area less than 100mm2 Hamanishi based on criteria measured at lumbar spine MRI in the follow-up from L1 to S1.

Conditions

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Spinal Stenosis of Lumbar Region

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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corticosteroids, analgesics oral pill

Oral Corticosteroids and oral analgesics

Group Type ACTIVE_COMPARATOR

predinose oral

Intervention Type DRUG

1 mg for kg for 3 wekees

placebo

oral placebo and oral analgesics

Group Type PLACEBO_COMPARATOR

placebo group

Intervention Type DRUG

use a oral placebo

Interventions

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predinose oral

1 mg for kg for 3 wekees

Intervention Type DRUG

placebo group

use a oral placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Low back pain and at least two of the following complaints in lower limbs: pain, weakness, burning or numbness that worsens with walking and improves with the cessation of walking.

Exclusion Criteria

* decompensated diabetes mellitus.
* Systemic hypertension and decompensated heart
* systemic disease affecting the lower limbs
* Neuromuscular Disease
* Use of steroids in the past 3 months.
* Patients with previous surgery of the thoracic or lumbar spine.
* cognitive disorder that interferes with the ability to understand or interpret the questionnaires
* Spondylolisthesis except degenerative
* degenerative scoliosis with Cobb angle of 10 °
Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Federal University of São Paulo

OTHER

Sponsor Role lead

Responsible Party

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Luiz Claudio Lacerda Rodrigues

assisten os spine surgeon group

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Santa Marcelina Hospital

São Paulo, São Paulo, Brazil

Site Status RECRUITING

Santa Mareclina Hospital

São Paulo, São Paulo, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Luiz Claudio l Rodrigues, doctor

Role: CONTACT

551120706317

jamil natour, prof doctor

Role: CONTACT

551155798087

Facility Contacts

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edna L Ohana, secretary

Role: primary

551120706317

Luiz Claudio L Rodrigues, docctor

Role: primary

551120706317

Other Identifiers

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1892/10

Identifier Type: -

Identifier Source: org_study_id