Diode Laser Treatment of Onychomycosis

NCT ID: NCT01452490

Last Updated: 2020-10-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-31

Study Completion Date

2013-08-31

Brief Summary

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The purpose of this study is to evaluate the V-Raser diode laser system with investigational Nail Fungus Handpiece in the treatment of onychomycosis.

Detailed Description

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Conditions

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Onychomycosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Even though this study has recruited more than 10 participants, it is a feasibility study, designed to test the prototype rather than measuring health outcomes. It is to confirm the operating specifications before beginning a full clinical trial.
Primary Study Purpose

DEVICE_FEASIBILITY

Blinding Strategy

NONE

Study Groups

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Diode Laser Treatment

Group Type EXPERIMENTAL

Diode Laser Treatment

Intervention Type DEVICE

Laser treatment once every 6 weeks, for a total of 4 treatment sessions

Interventions

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Diode Laser Treatment

Laser treatment once every 6 weeks, for a total of 4 treatment sessions

Intervention Type DEVICE

Other Intervention Names

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V-Raser

Eligibility Criteria

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Inclusion Criteria

* Confirmed subungual onychomycosis in a great toe that does not extend to the eponychium
* Fitzpatrick Skin Type I-IV
* Written and verbal informed consent
* Able to comply with study instructions and to return to the clinic for required visits
* Agrees to refrain from other active topical, laser or light-based treatment to the great toes
* Agrees to the use of Naftin Gel between the toes to prevent/control tinea pedis

Exclusion Criteria

* Pregnancy, breastfeeding or planning to become pregnant
* History of cutaneous photosensitivity, porphyria and hypersensitivity to porphyrins or photodermatoses
* Any skin pathology or condition that could interfere with the evaluation or that requires the use of interfering topical or systemic therapy
* Coagulation disorder or current use of anti-coagulation medication (including aspirin use of greater than 81 mg per day)
* Any condition which, in the investigator's opinion, would make it unsafe for the subject to participate
* Enrolled in an investigational drug or device trial, or has been treated with an investigational device or received an investigational drug within 30 days
* Oral Lamisil within 1 year, Sporanox or over-the-counter topicals within 1 month, or other prescription anti-fungal medications or topicals within 6 months
* Evidence of diabetic neuropathy or peripheral vascular disease related to diabetes, or a loss of protective sensation in the affected foot
* Psoriasis, lichen planus, infection involving the lunula, prior surgical treatment of the affected great toe within 1 year, or a history of trauma to the affected great toe
* Immunocompromised status, or with existing (or history of) cancer/skin malignancy
* Distal nail thickness of greater than 2mm in the affected great toenail
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ConBio, a Cynosure Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Darren Courtright, DPM

Role: PRINCIPAL_INVESTIGATOR

Shoreline Foot and Ankle Center

Locations

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Shoreline Foot and Ankle Center

New London, Connecticut, United States

Site Status

Shoreline Foot and Ankle Center

Westbrook, Connecticut, United States

Site Status

Countries

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United States

Other Identifiers

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D4-11-F

Identifier Type: -

Identifier Source: org_study_id