Investigation of the Effect of Food on the Bioavailability of a 25 mg Empagliflozin Tablet as Well as Assessment of Dose Proportionality Between 10 mg and 25 mg Empagliflozin Tablets Under Fasting Conditions.

NCT ID: NCT01451775

Last Updated: 2014-06-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-31

Brief Summary

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Investigation of food effect on the bioavailability of a 25 mg empagliflozin tablet and assessment of dose proportionality between 10 mg and 25 mg empagliflozin tablets under fasting conditions.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment A

high dose of empagliflozin after overnight fasting for at least 10 h

Group Type EXPERIMENTAL

Empagliflozin

Intervention Type DRUG

high dose of empagliflozin after overnight fasting for at least 10 h

Treatment B

high dose of empagliflozin after a standardised high fat breakfast

Group Type EXPERIMENTAL

Empagliflozin

Intervention Type DRUG

high dose of empagliflozin after a standardised high fat breakfast

Treatment C

low dose empagliflozin after overnight fasting for at least 10 h

Group Type EXPERIMENTAL

Empagliflozin

Intervention Type DRUG

low dose empagliflozin after overnight fasting for at least 10 h

Interventions

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Empagliflozin

high dose of empagliflozin after overnight fasting for at least 10 h

Intervention Type DRUG

Empagliflozin

low dose empagliflozin after overnight fasting for at least 10 h

Intervention Type DRUG

Empagliflozin

high dose of empagliflozin after a standardised high fat breakfast

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1\. Healthy male and female subjects

Exclusion Criteria

1\. Any relevant deviation from healthy conditions
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Boehringer Ingelheim

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

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1245.79.1 Boehringer Ingelheim Investigational Site

Biberach, , Germany

Site Status

Countries

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Germany

Other Identifiers

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2011-002836-13

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

1245.79

Identifier Type: -

Identifier Source: org_study_id

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