Athermal Nerve-sparing During Robotic-assisted Radical Prostatectomy Using a Hemostatic Matrix.

NCT ID: NCT01448798

Last Updated: 2011-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-31

Study Completion Date

2014-01-31

Brief Summary

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The purpose of this study is to evaluate the use of a hemostatic gelatine-thrombin matrix during athermal nerve-sparing prostate resection compared to conventional hemostasis using electrocautery in patients with localized prostate cancer and to investigate effects on postoperative erectile function and continence.

Detailed Description

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Conditions

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Prostate Cancer Erectile Dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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gelatine-thrombin matrix

Nerves-paring during robotic-assisted laparoscopic prostatectomy is conducted without mono- or bipolar electrocautery and clipping by using a hemostatic gelatine-thrombin matrix.

Group Type EXPERIMENTAL

Application of a hemostatic gelatin-thrombin matrix

Intervention Type PROCEDURE

Hemostatic gelatin-thrombin matrix is used for hemostasis during nerve-sparing dissection of the prostate.

Control

Nerve-sparing during robotic-assisted radical prostatectomy is conducted with the use of mono- and bipolar electrocautery and surgical clipping.

Group Type SHAM_COMPARATOR

Use of mono- and bipolar electrocautery and surgical clips

Intervention Type PROCEDURE

Mono- and bipolar electrocautery and surgical clips are used for hemostasis during nerve-sparing dissection of the prostate.

Interventions

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Application of a hemostatic gelatin-thrombin matrix

Hemostatic gelatin-thrombin matrix is used for hemostasis during nerve-sparing dissection of the prostate.

Intervention Type PROCEDURE

Use of mono- and bipolar electrocautery and surgical clips

Mono- and bipolar electrocautery and surgical clips are used for hemostasis during nerve-sparing dissection of the prostate.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patient age \>18
* Histologically proven prostate cancer ( Gleason \<8; PSA\<10ng/ml)
* Disease confined to prostate in clinical examination
* Preoperative IEEF-5-Score\>20
* Patient is able to give informed consent

Exclusion Criteria

* ASA IV-V
* Prior extensive abdominal surgery
* Signs for metastatic disease
* Known allergy against bovine material
* Patient is unable to give informed consent
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Johann Wolfgang Goethe University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Axel Haferkamp

Prof. Dr. med. Axel Haferkamp

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Axel Haferkamp, Prof.

Role: PRINCIPAL_INVESTIGATOR

Johann Wolfgang Goethe University Hospitals, Germany

Locations

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Johann Wolfgang Goethe University Hospital

Frankfurt/M., , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Axel Haferkamp, Prof.

Role: CONTACT

+49-69-6301-5352

Michael A Reiter, Dr.

Role: CONTACT

+49-69-6301-5352

Facility Contacts

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Axel Haferkamp, Prof.

Role: primary

+49-69-6301-5352

Michael A Reiter, Dr.

Role: backup

+49-69-6301-5352

Other Identifiers

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AnPro

Identifier Type: -

Identifier Source: org_study_id