A Bioequivalence Study Comparing Clopidogrel/Aspirin Combination Tablet With Coadministration of Clopidogrel and Aspirin

NCT ID: NCT01448330

Last Updated: 2011-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2011-09-30

Brief Summary

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The purpose of this study is to evaluate pharmacokinetics and safety after oral administration of clopidogrel and aspirin in free combination as HCP0911.

Detailed Description

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Conditions

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Healthy

Keywords

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clopidogrel aspinin combination

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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HCP0911

clopidogrel/aspirin combination tablet

Group Type EXPERIMENTAL

HCP0911 / clopidogrel, aspirin

Intervention Type DRUG

combination tablet vs coadministration

clopidorel and aspirin

coadministration of clopidogrel and aspirin

Group Type ACTIVE_COMPARATOR

HCP0911 / clopidogrel, aspirin

Intervention Type DRUG

combination tablet vs coadministration

Interventions

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HCP0911 / clopidogrel, aspirin

combination tablet vs coadministration

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age between 20 and 55
* Signed informed consent

Exclusion Criteria

* Has a history of hypersensitivity to IP ingredients
* Hypotension or hypertension
* Has a history of acute infection within 14days of screening
Minimum Eligible Age

20 Years

Maximum Eligible Age

55 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Hanmi Pharmaceutical Company Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jae-wook Ko, MD

Role: PRINCIPAL_INVESTIGATOR

Samsung Medical Center

Locations

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Samsung medical center

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Jung JA, Kim TE, Kim JR, Kim MJ, Huh W, Park KM, Lee SY, Ko JW. The pharmacokinetics and safety of a fixed-dose combination of acetylsalicylic acid and clopidogrel compared with the concurrent administration of acetylsalicylic acid and clopidogrel in healthy subjects: a randomized, open-label, 2-sequence, 2-period, single-dose crossover study. Clin Ther. 2013 Jul;35(7):985-94. doi: 10.1016/j.clinthera.2013.05.015.

Reference Type DERIVED
PMID: 23870608 (View on PubMed)

Other Identifiers

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HM-CPAS-101

Identifier Type: -

Identifier Source: org_study_id