Evaluation of Interests of FIT Therapy on Diabetics Children Insulin-dependent

NCT ID: NCT01443741

Last Updated: 2011-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

88 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-01-31

Study Completion Date

2015-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Evaluation of interests of the functional insulin therapy (FIT Therapy) on metabolic control, hypoglycemia prevention and life quality of diabetics children insulin-dependent treated with insulin pump.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Open multicenter randomized study of one year, evaluating two groups of 44 children with diabetes mellitus (diabetes over 1 year) treated with insulin pump, one group by traditional way (fixed doses of insulin and meals providing stable quantities complex carbohydrates) and the other group by FIT Therapy.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Diabetes Insulin Dependent

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

FIT Therapy Diabetes mellitus Insulin pump Pediatric

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

FIT Therapy

Patient with functional insulin therapy

Group Type ACTIVE_COMPARATOR

Therapeutic education

Intervention Type OTHER

Specific program for FIT Therapy and specific program for traditional way

Traditional way

Patient with traditional way

Group Type ACTIVE_COMPARATOR

Therapeutic education

Intervention Type OTHER

Specific program for FIT Therapy and specific program for traditional way

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Therapeutic education

Specific program for FIT Therapy and specific program for traditional way

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Functional insulin therapy Traditional way (fixed doses of insulin)

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* aged 1-17 years
* diabetic for at least 1 year
* whose HbA1c is between 7.6 and 10% (7.6% \<HbA1C \<10%)
* treated with insulin pump
* agreeing to perform at least three blood glucose/day
* willing to follow the treatment with functional insulin therapy if necessary

Exclusion Criteria

* Ages \<1 year or\> 17 years
* Duration of diabetes \<1 year
* HbA1c \<7.6% or HbA1c\> 10%
* Treatment-by multiple injections
* Mental disability
* Refusal to adhere to the constraints of the study
* Language barrier, preventing any understanding or cooperation
* Eating behavior-type anorexia or bulimia
* Pregnancy
* Use of alcohol or drugs
* Severe chronic or genetic pathology other than diabetes
* Participation in another clinical study or refusal to participate in the study
Minimum Eligible Age

1 Year

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University Hospital, Angers

OTHER_GOV

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Régis Coutant, MD PhD

Role: PRINCIPAL_INVESTIGATOR

UH Angers

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University Hospital of Lyon

Lyon, Auvergne-Rhône-Alpes, France

Site Status

University Hospital of Brest

Brest, Brittany Region, France

Site Status

University Hospital of Tours

Tours, Centre-Val de Loire, France

Site Status

University Hospital of Toulouse

Toulouse, Midi-Pyrénées, France

Site Status

University Hospital of Angers Service of Pediatric Diabetology and Endocrinology

Angers, Pays de Loire, France

Site Status

University Hospital of Nantes

Nantes, Pays de Loire, France

Site Status

Countries

Review the countries where the study has at least one active or historical site.

France

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Régis Coutant, MD PhD

Role: CONTACT

Phone: 33(2)41-35-56-55

Email: [email protected]

Natacha Bouhours-Nouet, MD

Role: CONTACT

Phone: 33(2)41-35-44-06

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Marc Nicolino, MD-PhD

Role: primary

Chantal Metz, MD

Role: primary

Myriam Pépin-Donat, MD

Role: primary

Claire Le Tallec, MD

Role: primary

Regis Coutant, MD-PhD

Role: primary

Natacha Bouhours-Nouet, MD

Role: backup

Sabine Baron, MD

Role: primary

References

Explore related publications, articles, or registry entries linked to this study.

Langewitz W, Wossmer B, Iseli J, Berger W. Psychological and metabolic improvement after an outpatient teaching program for functional intensified insulin therapy (FIT). Diabetes Res Clin Pract. 1997 Sep;37(3):157-64. doi: 10.1016/s0168-8227(97)00071-5.

Reference Type BACKGROUND
PMID: 9306036 (View on PubMed)

Hartemann-Heurtier A, Sachon C, Masseboeuf N, Corset E, Grimaldi A. Functional intensified insulin therapy with short-acting insulin analog: effects on HbA1c and frequency of severe hypoglycemia. An observational cohort study. Diabetes Metab. 2003 Feb;29(1):53-7. doi: 10.1016/s1262-3636(07)70007-1.

Reference Type BACKGROUND
PMID: 12629448 (View on PubMed)

Samann A, Muhlhauser I, Bender R, Kloos Ch, Muller UA. Glycaemic control and severe hypoglycaemia following training in flexible, intensive insulin therapy to enable dietary freedom in people with type 1 diabetes: a prospective implementation study. Diabetologia. 2005 Oct;48(10):1965-70. doi: 10.1007/s00125-005-1905-1. Epub 2005 Aug 18.

Reference Type BACKGROUND
PMID: 16132954 (View on PubMed)

Lowe J, Linjawi S, Mensch M, James K, Attia J. Flexible eating and flexible insulin dosing in patients with diabetes: Results of an intensive self-management course. Diabetes Res Clin Pract. 2008 Jun;80(3):439-43. doi: 10.1016/j.diabres.2008.02.003. Epub 2008 Mar 18.

Reference Type BACKGROUND
PMID: 18353485 (View on PubMed)

Grimm JJ, Ybarra J, Berne C, Muchnick S, Golay A. A new table for prevention of hypoglycaemia during physical activity in type 1 diabetic patients. Diabetes Metab. 2004 Nov;30(5):465-70. doi: 10.1016/s1262-3636(07)70144-1.

Reference Type BACKGROUND
PMID: 15671916 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

PHRC 2009- 03

Identifier Type: -

Identifier Source: org_study_id