Ascorbyl Peroxide Association With Bronchopulmonary Dysplasia

NCT ID: NCT01439295

Last Updated: 2015-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

51 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-08-31

Study Completion Date

2015-11-30

Brief Summary

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Urinary ascorbyl peroxide level in the first week of life will be a good predictor of Bronchopulmonary dysplasia (BPD) in preterm infants less than 33 weeks of gestation.

Detailed Description

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This study uses ascorbyl peroxide as representative of oxidative stress in premature infants on parenteral nutrition and aims to test the correlation of this metabolite and the different major neonatal outcomes 'mainly bronchopulmonary dysplasia).

Conditions

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Bronchopulmonary Dysplasia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Preterm less than 33 weeks

This cohort will be composed of premature infants born before 33 weeks of gestational age, admitted to the neonatal intensive care unit at Sainte-Justine hospital and receiving parenteral nutrition (PN) during their first week of life.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Preterm infants less than 33 weeks of gestation\<
* Admission to CHU Sainte-JUstien neonatal intensive care unit
* Receiving Parenteral nutrition during the first week of life
* Parental consent

Exclusion Criteria

* Major congenital anomalies
* Sever perinatal asphyxia
Minimum Eligible Age

23 Weeks

Maximum Eligible Age

32 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Canadian Institutes of Health Research (CIHR)

OTHER_GOV

Sponsor Role collaborator

St. Justine's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ibrahim Mohamed

Adjunct professor of peditarics, division of neonatology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ibrahim Mohamed, Mb CHB

Role: PRINCIPAL_INVESTIGATOR

University of Montreal, Sainte Justine Hospital

Jean-claude Lavoie, PhD

Role: STUDY_DIRECTOR

University of Montreal, Sainte-Justine hospital research center

Locations

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University of Montreal, Sainte-Justine Hospital

Montreal, Quebec, Canada

Site Status

Countries

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Canada

Related Links

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http://journals.lww.com/pedresearch/Fulltext/2010/09000/Neonatal_Exposure_to_Oxidants_Induces_Later_in.2.aspx

Neonatal Exposure to Oxidants Induces Later in Life a Metabolic Response Associated to a Phenotype of Energy Deficiency in an Animal Model of Total Parenteral Nutrition

http://www.pediatricsdigest.mobi/content/99/3/e6.full

Admixture of a Multivitamin Preparation to Parenteral Nutrition: The Major Contributor to In Vitro Generation of Peroxides

http://journals.lww.com/pedresearch/pages/articleviewer.aspx?year=1998&issue=05000&article=00007&type=abstract

Paradoxical Role of Ascorbic Acid and Riboflavin in Solutions of Total Parenteral Nutrition: Implication in Photoinduced Peroxide Generation

Other Identifiers

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CIHR246505

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

University of Montreal

Identifier Type: -

Identifier Source: org_study_id